The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

Genetically engineered mouse models of cancer are useful in identifying oncogenes and tumour suppressors. Here, the authors use gene expression profiles to generate a catalogue of copy number aberrations in 45 mouse models, and compare mouse and human tumours to identify additional drivers of tumori...

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Autores principales:	Uri Ben-David, Gavin Ha, Prasidda Khadka, Xin Jin, Bang Wong, Lude Franke, Todd R. Golub
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d7cc200cdfe438c8f082db13a6e80f0
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spelling	oai:doaj.org-article:5d7cc200cdfe438c8f082db13a6e80f02021-12-02T15:35:43ZThe landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis10.1038/ncomms121602041-1723https://doaj.org/article/5d7cc200cdfe438c8f082db13a6e80f02016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12160https://doaj.org/toc/2041-1723Genetically engineered mouse models of cancer are useful in identifying oncogenes and tumour suppressors. Here, the authors use gene expression profiles to generate a catalogue of copy number aberrations in 45 mouse models, and compare mouse and human tumours to identify additional drivers of tumorigenesis.Uri Ben-DavidGavin HaPrasidda KhadkaXin JinBang WongLude FrankeTodd R. GolubNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Uri Ben-David Gavin Ha Prasidda Khadka Xin Jin Bang Wong Lude Franke Todd R. Golub The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
description	Genetically engineered mouse models of cancer are useful in identifying oncogenes and tumour suppressors. Here, the authors use gene expression profiles to generate a catalogue of copy number aberrations in 45 mouse models, and compare mouse and human tumours to identify additional drivers of tumorigenesis.
format	article
author	Uri Ben-David Gavin Ha Prasidda Khadka Xin Jin Bang Wong Lude Franke Todd R. Golub
author_facet	Uri Ben-David Gavin Ha Prasidda Khadka Xin Jin Bang Wong Lude Franke Todd R. Golub
author_sort	Uri Ben-David
title	The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
title_short	The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
title_full	The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
title_fullStr	The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
title_full_unstemmed	The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
title_sort	landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5d7cc200cdfe438c8f082db13a6e80f0
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The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

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