Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence

Since Banting and Best isolated insulin in the 1920s, dramatic progress has been made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely injection to maintain optimal glycemic control are often challenging for T1DM patients and their families because they require...

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Autores principales:	Sun Joon Moon, Inha Jung, Cheol-Young Park
Formato:	article
Lenguaje:	EN
Publicado:	Korean Diabetes Association 2021
Materias:	blood glucose self-monitoring diabetes mellitus, type 1 hypoglycemia insulin infusion systems pancreas, artificial wearable electronic devices Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5d7d1bb4460740ed8982101ff13b0d9e
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spelling	oai:doaj.org-article:5d7d1bb4460740ed8982101ff13b0d9e2021-12-01T05:07:51ZCurrent Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence2233-60792233-608710.4093/dmj.2021.0177https://doaj.org/article/5d7d1bb4460740ed8982101ff13b0d9e2021-11-01T00:00:00Zhttp://www.e-dmj.org/upload/pdf/dmj-2021-0177.pdfhttps://doaj.org/toc/2233-6079https://doaj.org/toc/2233-6087Since Banting and Best isolated insulin in the 1920s, dramatic progress has been made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely injection to maintain optimal glycemic control are often challenging for T1DM patients and their families because they require frequent blood glucose checks. In recent years, technological advances in insulin pumps and continuous glucose monitoring systems have created paradigm shifts in T1DM care that are being extended to develop artificial pancreas systems (APSs). Numerous studies that demonstrate the superiority of glycemic control offered by APSs over those offered by conventional treatment are still being published, and rapid commercialization and use in actual practice have already begun. Given this rapid development, keeping up with the latest knowledge in an organized way is confusing for both patients and medical staff. Herein, we explore the history, clinical evidence, and current state of APSs, focusing on various development groups and the commercialization status. We also discuss APS development in groups outside the usual T1DM patients and the administration of adjunct agents, such as amylin analogues, in APSs.Sun Joon MoonInha JungCheol-Young ParkKorean Diabetes Associationarticleblood glucose self-monitoringdiabetes mellitus, type 1hypoglycemiainsulin infusion systemspancreas, artificialwearable electronic devicesDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENDiabetes & Metabolism Journal, Vol 45, Iss 6, Pp 813-839 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood glucose self-monitoring diabetes mellitus, type 1 hypoglycemia insulin infusion systems pancreas, artificial wearable electronic devices Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	blood glucose self-monitoring diabetes mellitus, type 1 hypoglycemia insulin infusion systems pancreas, artificial wearable electronic devices Diseases of the endocrine glands. Clinical endocrinology RC648-665 Sun Joon Moon Inha Jung Cheol-Young Park Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
description	Since Banting and Best isolated insulin in the 1920s, dramatic progress has been made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely injection to maintain optimal glycemic control are often challenging for T1DM patients and their families because they require frequent blood glucose checks. In recent years, technological advances in insulin pumps and continuous glucose monitoring systems have created paradigm shifts in T1DM care that are being extended to develop artificial pancreas systems (APSs). Numerous studies that demonstrate the superiority of glycemic control offered by APSs over those offered by conventional treatment are still being published, and rapid commercialization and use in actual practice have already begun. Given this rapid development, keeping up with the latest knowledge in an organized way is confusing for both patients and medical staff. Herein, we explore the history, clinical evidence, and current state of APSs, focusing on various development groups and the commercialization status. We also discuss APS development in groups outside the usual T1DM patients and the administration of adjunct agents, such as amylin analogues, in APSs.
format	article
author	Sun Joon Moon Inha Jung Cheol-Young Park
author_facet	Sun Joon Moon Inha Jung Cheol-Young Park
author_sort	Sun Joon Moon
title	Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
title_short	Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
title_full	Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
title_fullStr	Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
title_full_unstemmed	Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence
title_sort	current advances of artificial pancreas systems: a comprehensive review of the clinical evidence
publisher	Korean Diabetes Association
publishDate	2021
url	https://doaj.org/article/5d7d1bb4460740ed8982101ff13b0d9e
work_keys_str_mv	AT sunjoonmoon currentadvancesofartificialpancreassystemsacomprehensivereviewoftheclinicalevidence AT inhajung currentadvancesofartificialpancreassystemsacomprehensivereviewoftheclinicalevidence AT cheolyoungpark currentadvancesofartificialpancreassystemsacomprehensivereviewoftheclinicalevidence
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Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence

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