A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites

Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids, and are essential for rhoptry secretion and invasi...

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Autores principales:	Catherine Suarez, Gaëlle Lentini, Raghavendran Ramaswamy, Marjorie Maynadier, Eleonora Aquilini, Laurence Berry-Sterkers, Michael Cipriano, Allan L. Chen, Peter Bradley, Boris Striepen, Martin J. Boulanger, Maryse Lebrun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b
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spelling	oai:doaj.org-article:5d7eb981430d428a86981e90c449cc6b2021-12-02T16:58:26ZA lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites10.1038/s41467-019-11979-z2041-1723https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11979-zhttps://doaj.org/toc/2041-1723Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids, and are essential for rhoptry secretion and invasion.Catherine SuarezGaëlle LentiniRaghavendran RamaswamyMarjorie MaynadierEleonora AquiliniLaurence Berry-SterkersMichael CiprianoAllan L. ChenPeter BradleyBoris StriepenMartin J. BoulangerMaryse LebrunNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Catherine Suarez Gaëlle Lentini Raghavendran Ramaswamy Marjorie Maynadier Eleonora Aquilini Laurence Berry-Sterkers Michael Cipriano Allan L. Chen Peter Bradley Boris Striepen Martin J. Boulanger Maryse Lebrun A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
description	Plasmodium and Toxoplasma parasites rely on rhoptry exocytosis for invasion, but the underlying mechanism is not known. Here, Suarez et al. characterize rhoptry apical surface proteins (RASP) that localize to the rhoptry cap and bind charged lipids, and are essential for rhoptry secretion and invasion.
format	article
author	Catherine Suarez Gaëlle Lentini Raghavendran Ramaswamy Marjorie Maynadier Eleonora Aquilini Laurence Berry-Sterkers Michael Cipriano Allan L. Chen Peter Bradley Boris Striepen Martin J. Boulanger Maryse Lebrun
author_facet	Catherine Suarez Gaëlle Lentini Raghavendran Ramaswamy Marjorie Maynadier Eleonora Aquilini Laurence Berry-Sterkers Michael Cipriano Allan L. Chen Peter Bradley Boris Striepen Martin J. Boulanger Maryse Lebrun
author_sort	Catherine Suarez
title	A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
title_short	A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
title_full	A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
title_fullStr	A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
title_full_unstemmed	A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites
title_sort	lipid-binding protein mediates rhoptry discharge and invasion in plasmodium falciparum and toxoplasma gondii parasites
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5d7eb981430d428a86981e90c449cc6b
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A lipid-binding protein mediates rhoptry discharge and invasion in Plasmodium falciparum and Toxoplasma gondii parasites

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