Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening at Oct4 bound DNA early during reprogramming to pl...

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Autores principales:	Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17
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spelling	oai:doaj.org-article:5d839fd6128d4d118a7cbf72a69b4f172021-12-02T17:01:45ZPluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox210.1038/s41467-019-11054-72041-1723https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f172019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11054-7https://doaj.org/toc/2041-1723Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening at Oct4 bound DNA early during reprogramming to pluripotency.Vikas MalikLaura V. GlaserDennis ZimmerSergiy VelychkoMingxi WengMarkus HolznerMarius ArendYanpu ChenYogesh SrivastavaVeeramohan VeerapandianZahir ShahMiguel A. EstebanHuating WangJiekai ChenHans R. SchölerAndrew P. HutchinsSebastiaan H. MeijsingSebastian PottRalf JauchNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vikas Malik Laura V. Glaser Dennis Zimmer Sergiy Velychko Mingxi Weng Markus Holzner Marius Arend Yanpu Chen Yogesh Srivastava Veeramohan Veerapandian Zahir Shah Miguel A. Esteban Huating Wang Jiekai Chen Hans R. Schöler Andrew P. Hutchins Sebastiaan H. Meijsing Sebastian Pott Ralf Jauch Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
description	Oct4, along with Sox2 and Klf4 can induce pluripotency, but structurally similar factors like Oct6 cannot. Here, using pluripotency competent and incompetent factors, the authors show that Sox2 plays a dominant role in facilitating chromatin opening at Oct4 bound DNA early during reprogramming to pluripotency.
format	article
author	Vikas Malik Laura V. Glaser Dennis Zimmer Sergiy Velychko Mingxi Weng Markus Holzner Marius Arend Yanpu Chen Yogesh Srivastava Veeramohan Veerapandian Zahir Shah Miguel A. Esteban Huating Wang Jiekai Chen Hans R. Schöler Andrew P. Hutchins Sebastiaan H. Meijsing Sebastian Pott Ralf Jauch
author_facet	Vikas Malik Laura V. Glaser Dennis Zimmer Sergiy Velychko Mingxi Weng Markus Holzner Marius Arend Yanpu Chen Yogesh Srivastava Veeramohan Veerapandian Zahir Shah Miguel A. Esteban Huating Wang Jiekai Chen Hans R. Schöler Andrew P. Hutchins Sebastiaan H. Meijsing Sebastian Pott Ralf Jauch
author_sort	Vikas Malik
title	Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
title_short	Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
title_full	Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
title_fullStr	Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
title_full_unstemmed	Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2
title_sort	pluripotency reprogramming by competent and incompetent pou factors uncovers temporal dependency for oct4 and sox2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5d839fd6128d4d118a7cbf72a69b4f17
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Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

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