Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.

<h4>Background</h4>Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer.<h4>Methods</h4>This was a secondary analysis of baseline data f...

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Autores principales:	Mallory R Taylor, Michelle M Garrison, Abby R Rosenberg
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d8851e90ae94ca99d5002ebd2b89d11
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spelling	oai:doaj.org-article:5d8851e90ae94ca99d5002ebd2b89d112021-12-02T20:04:21ZHeart rate variability and psychosocial symptoms in adolescents and young adults with cancer.1932-620310.1371/journal.pone.0259385https://doaj.org/article/5d8851e90ae94ca99d5002ebd2b89d112021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0259385https://doaj.org/toc/1932-6203<h4>Background</h4>Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer.<h4>Methods</h4>This was a secondary analysis of baseline data from a randomized trial testing a resilience intervention in AYAs with cancer. Two widely used HRV metrics, the standard deviation of normal to normal beats (SDNN) and root mean square of successive differences (RMSSD), were derived from electrocardiograms. Patient-reported outcome (PRO) survey measures included quality of life, anxiety, depression, distress, and resilience. Linear regression models were used to test associations between HRV and PRO scores. The Wilcoxon rank sum test was used to test differences in median HRV values among participant subgroups.<h4>Results</h4>Among the n = 76 patients with available electrocardiograms, the mean age was 16 years (SD 3y), 63% were white, and leukemia/lymphoma was the most common diagnosis. Compared to healthy adolescents, AYAs with cancer had lower median HRV (SDNN [Females: 31.9 (12.8-50.7) vs 66.4 (46.0-86.8), p<0.01; Males: 29.9 (11.5-47.9) vs 63.2 (48.4-84.6), p<0.01]; RMSSD [Females: 28.2 (11.1-45.5) vs 69.0 (49.1-99.6), p<0.01; Males: 27.9 (8.6-48.6) vs 58.7 (44.8-88.2), p<0.01]). There was no statistically significant association between PRO measures and SDNN or RMSSD in either an unadjusted or adjusted linear regression models.<h4>Conclusion</h4>In this secondary analysis, we did not find an association between HRV and psychosocial PROs among AYAs with cancer. HRV measures were lower than for healthy adolescents. Larger prospective studies in AYA biopsychosocial research are needed.Mallory R TaylorMichelle M GarrisonAbby R RosenbergPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0259385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mallory R Taylor Michelle M Garrison Abby R Rosenberg Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
description	<h4>Background</h4>Heart Rate Variability (HRV) is a valid, scalable biomarker of stress. We aimed to examine associations between HRV and psychosocial outcomes in adolescents and young adults (AYAs) with cancer.<h4>Methods</h4>This was a secondary analysis of baseline data from a randomized trial testing a resilience intervention in AYAs with cancer. Two widely used HRV metrics, the standard deviation of normal to normal beats (SDNN) and root mean square of successive differences (RMSSD), were derived from electrocardiograms. Patient-reported outcome (PRO) survey measures included quality of life, anxiety, depression, distress, and resilience. Linear regression models were used to test associations between HRV and PRO scores. The Wilcoxon rank sum test was used to test differences in median HRV values among participant subgroups.<h4>Results</h4>Among the n = 76 patients with available electrocardiograms, the mean age was 16 years (SD 3y), 63% were white, and leukemia/lymphoma was the most common diagnosis. Compared to healthy adolescents, AYAs with cancer had lower median HRV (SDNN [Females: 31.9 (12.8-50.7) vs 66.4 (46.0-86.8), p<0.01; Males: 29.9 (11.5-47.9) vs 63.2 (48.4-84.6), p<0.01]; RMSSD [Females: 28.2 (11.1-45.5) vs 69.0 (49.1-99.6), p<0.01; Males: 27.9 (8.6-48.6) vs 58.7 (44.8-88.2), p<0.01]). There was no statistically significant association between PRO measures and SDNN or RMSSD in either an unadjusted or adjusted linear regression models.<h4>Conclusion</h4>In this secondary analysis, we did not find an association between HRV and psychosocial PROs among AYAs with cancer. HRV measures were lower than for healthy adolescents. Larger prospective studies in AYA biopsychosocial research are needed.
format	article
author	Mallory R Taylor Michelle M Garrison Abby R Rosenberg
author_facet	Mallory R Taylor Michelle M Garrison Abby R Rosenberg
author_sort	Mallory R Taylor
title	Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
title_short	Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
title_full	Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
title_fullStr	Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
title_full_unstemmed	Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
title_sort	heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5d8851e90ae94ca99d5002ebd2b89d11
work_keys_str_mv	AT malloryrtaylor heartratevariabilityandpsychosocialsymptomsinadolescentsandyoungadultswithcancer AT michellemgarrison heartratevariabilityandpsychosocialsymptomsinadolescentsandyoungadultswithcancer AT abbyrrosenberg heartratevariabilityandpsychosocialsymptomsinadolescentsandyoungadultswithcancer
_version_	1718375604033683456

Heart rate variability and psychosocial symptoms in adolescents and young adults with cancer.

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