COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy

The potential relationship between diabetes and COVID-19 has been evaluated. However, new knowledge is rapidly emerging. In this study, we systematically reviewed the relationship between viral cell surface receptors (ACE2, AXL, CD147, DC-SIGN, L-SIGN and DPP4) and SARS-CoV-2 infection risk, and emp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lingli Xie, Ziying Zhang, Qian Wang, Yangwen Chen, Dexue Lu, Weihua Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	diabetes mellitus ACE2 (angiotensin converting enzyme 2) COVID - 19 SARS- CoV-2 therapeutic management receptor Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5d89f52f8dc4470b98867d37ff096a95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d89f52f8dc4470b98867d37ff096a95
record_format	dspace
spelling	oai:doaj.org-article:5d89f52f8dc4470b98867d37ff096a952021-11-19T05:39:26ZCOVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy1664-239210.3389/fendo.2021.772865https://doaj.org/article/5d89f52f8dc4470b98867d37ff096a952021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.772865/fullhttps://doaj.org/toc/1664-2392The potential relationship between diabetes and COVID-19 has been evaluated. However, new knowledge is rapidly emerging. In this study, we systematically reviewed the relationship between viral cell surface receptors (ACE2, AXL, CD147, DC-SIGN, L-SIGN and DPP4) and SARS-CoV-2 infection risk, and emphasized the implications of ACE2 on SARS-CoV-2 infection and COVID-19 pathogenesis. Besides, we updated on the two-way interactions between diabetes and COVID-19, as well as the treatment options for COVID-19 comorbid patients from the perspective of ACE2. The efficacies of various clinical chemotherapeutic options, including anti-diabetic drugs, renin-angiotensin-aldosterone system inhibitors, lipid-lowering drugs, anticoagulants, and glucocorticoids for COVID-19 positive diabetic patients were discussed. Moreover, we reviewed the significance of two different forms of ACE2 (mACE2 and sACE2) and gender on COVID-19 susceptibility and severity. This review summarizes COVID-19 pathophysiology and the best strategies for clinical management of diabetes patients with COVID-19.Lingli XieZiying ZhangQian WangYangwen ChenDexue LuWeihua WuFrontiers Media S.A.articlediabetes mellitusACE2 (angiotensin converting enzyme 2)COVID - 19SARS- CoV-2therapeutic managementreceptorDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus ACE2 (angiotensin converting enzyme 2) COVID - 19 SARS- CoV-2 therapeutic management receptor Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	diabetes mellitus ACE2 (angiotensin converting enzyme 2) COVID - 19 SARS- CoV-2 therapeutic management receptor Diseases of the endocrine glands. Clinical endocrinology RC648-665 Lingli Xie Ziying Zhang Qian Wang Yangwen Chen Dexue Lu Weihua Wu COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
description	The potential relationship between diabetes and COVID-19 has been evaluated. However, new knowledge is rapidly emerging. In this study, we systematically reviewed the relationship between viral cell surface receptors (ACE2, AXL, CD147, DC-SIGN, L-SIGN and DPP4) and SARS-CoV-2 infection risk, and emphasized the implications of ACE2 on SARS-CoV-2 infection and COVID-19 pathogenesis. Besides, we updated on the two-way interactions between diabetes and COVID-19, as well as the treatment options for COVID-19 comorbid patients from the perspective of ACE2. The efficacies of various clinical chemotherapeutic options, including anti-diabetic drugs, renin-angiotensin-aldosterone system inhibitors, lipid-lowering drugs, anticoagulants, and glucocorticoids for COVID-19 positive diabetic patients were discussed. Moreover, we reviewed the significance of two different forms of ACE2 (mACE2 and sACE2) and gender on COVID-19 susceptibility and severity. This review summarizes COVID-19 pathophysiology and the best strategies for clinical management of diabetes patients with COVID-19.
format	article
author	Lingli Xie Ziying Zhang Qian Wang Yangwen Chen Dexue Lu Weihua Wu
author_facet	Lingli Xie Ziying Zhang Qian Wang Yangwen Chen Dexue Lu Weihua Wu
author_sort	Lingli Xie
title	COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
title_short	COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
title_full	COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
title_fullStr	COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
title_full_unstemmed	COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy
title_sort	covid-19 and diabetes: a comprehensive review of angiotensin converting enzyme 2, mutual effects and pharmacotherapy
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d89f52f8dc4470b98867d37ff096a95
work_keys_str_mv	AT linglixie covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy AT ziyingzhang covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy AT qianwang covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy AT yangwenchen covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy AT dexuelu covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy AT weihuawu covid19anddiabetesacomprehensivereviewofangiotensinconvertingenzyme2mutualeffectsandpharmacotherapy
_version_	1718420375664066560

COVID-19 and Diabetes: A Comprehensive Review of Angiotensin Converting Enzyme 2, Mutual Effects and Pharmacotherapy

Ejemplares similares