Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynami...

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Autores principales:	David Haselbach, Jil Schrader, Felix Lambrecht, Fabian Henneberg, Ashwin Chari, Holger Stark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d9161ad03444a5093bee737ed564dd5
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spelling	oai:doaj.org-article:5d9161ad03444a5093bee737ed564dd52021-12-02T15:38:54ZLong-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs10.1038/ncomms155782041-1723https://doaj.org/article/5d9161ad03444a5093bee737ed564dd52017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15578https://doaj.org/toc/2041-1723The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome.David HaselbachJil SchraderFelix LambrechtFabian HennebergAshwin ChariHolger StarkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Haselbach Jil Schrader Felix Lambrecht Fabian Henneberg Ashwin Chari Holger Stark Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
description	The proteasome regulates several important cellular processes and has been identified as a target for therapeutic interventions. Here the authors map the conformational and energy landscape of the 26S proteasome upon Oprozomib binding and uncover long-range allosteric effects that control the dynamic behaviour of the proteasome.
format	article
author	David Haselbach Jil Schrader Felix Lambrecht Fabian Henneberg Ashwin Chari Holger Stark
author_facet	David Haselbach Jil Schrader Felix Lambrecht Fabian Henneberg Ashwin Chari Holger Stark
author_sort	David Haselbach
title	Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
title_short	Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
title_full	Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
title_fullStr	Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
title_full_unstemmed	Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs
title_sort	long-range allosteric regulation of the human 26s proteasome by 20s proteasome-targeting cancer drugs
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5d9161ad03444a5093bee737ed564dd5
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Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs

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