A survival analysis of surgically treated incidental low-grade glioma patients

Abstract To evaluate the surgical effect on survival in patients with incidental low-grade glioma (LGG) through comparison between asymptomatic and symptomatic patients. The medical records of surgically treated adult cerebral incidental LGG (iLGG) patients in our department between January 2008 and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lingcheng Zeng, Qi Mei, Hua Li, Changshu Ke, Jiasheng Yu, Jian Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d932271a0674da8adf47625cd56fc04
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d932271a0674da8adf47625cd56fc04
record_format	dspace
spelling	oai:doaj.org-article:5d932271a0674da8adf47625cd56fc042021-12-02T16:45:39ZA survival analysis of surgically treated incidental low-grade glioma patients10.1038/s41598-021-88023-y2045-2322https://doaj.org/article/5d932271a0674da8adf47625cd56fc042021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88023-yhttps://doaj.org/toc/2045-2322Abstract To evaluate the surgical effect on survival in patients with incidental low-grade glioma (LGG) through comparison between asymptomatic and symptomatic patients. The medical records of surgically treated adult cerebral incidental LGG (iLGG) patients in our department between January 2008 and December 2015 were retrospectively reviewed. The survival of patients was calculated starting from the initial imaging diagnosis. Factors related to progression-free survival (PFS), overall survival (OS) and malignant progression-free survival (MPFS) were statistically analyzed. Seventy-five iLGG patients underwent surgery: 49 in the asymptomatic group, who underwent surgery in the asymptomatic period, and 26 in the symptomatic group, who underwent surgery after the tumor had grown and the patients had developed tumor-related symptoms. Significantly more tumors were initially located adjacent to the functional area in the symptomatic group than in the asymptomatic group (P < 0.05), but there was no significant difference in the total resection rate between the two groups. The incidence of postoperative complications (15.4%) and postoperative epilepsy (23.1%) was higher in the symptomatic group than in the asymptomatic group (4.1% and 10.2%, respectively). Multivariate analysis showed that surgical timing, namely, surgery performed before or after symptom occurrence, had no significant effect on PFS, OS or MPFS, while total resection significantly prolonged PFS, OS and MPFS, and the pathology of oligodendroglioma was positively correlated with PFS and OS (P < 0.05). Surgical timing for iLGGs should facilitate total resection. If total resection can be achieved, even after symptom occurrence, patients can achieve comparable survival benefits to those treated with surgery in the asymptomatic phase.Lingcheng ZengQi MeiHua LiChangshu KeJiasheng YuJian ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingcheng Zeng Qi Mei Hua Li Changshu Ke Jiasheng Yu Jian Chen A survival analysis of surgically treated incidental low-grade glioma patients
description	Abstract To evaluate the surgical effect on survival in patients with incidental low-grade glioma (LGG) through comparison between asymptomatic and symptomatic patients. The medical records of surgically treated adult cerebral incidental LGG (iLGG) patients in our department between January 2008 and December 2015 were retrospectively reviewed. The survival of patients was calculated starting from the initial imaging diagnosis. Factors related to progression-free survival (PFS), overall survival (OS) and malignant progression-free survival (MPFS) were statistically analyzed. Seventy-five iLGG patients underwent surgery: 49 in the asymptomatic group, who underwent surgery in the asymptomatic period, and 26 in the symptomatic group, who underwent surgery after the tumor had grown and the patients had developed tumor-related symptoms. Significantly more tumors were initially located adjacent to the functional area in the symptomatic group than in the asymptomatic group (P < 0.05), but there was no significant difference in the total resection rate between the two groups. The incidence of postoperative complications (15.4%) and postoperative epilepsy (23.1%) was higher in the symptomatic group than in the asymptomatic group (4.1% and 10.2%, respectively). Multivariate analysis showed that surgical timing, namely, surgery performed before or after symptom occurrence, had no significant effect on PFS, OS or MPFS, while total resection significantly prolonged PFS, OS and MPFS, and the pathology of oligodendroglioma was positively correlated with PFS and OS (P < 0.05). Surgical timing for iLGGs should facilitate total resection. If total resection can be achieved, even after symptom occurrence, patients can achieve comparable survival benefits to those treated with surgery in the asymptomatic phase.
format	article
author	Lingcheng Zeng Qi Mei Hua Li Changshu Ke Jiasheng Yu Jian Chen
author_facet	Lingcheng Zeng Qi Mei Hua Li Changshu Ke Jiasheng Yu Jian Chen
author_sort	Lingcheng Zeng
title	A survival analysis of surgically treated incidental low-grade glioma patients
title_short	A survival analysis of surgically treated incidental low-grade glioma patients
title_full	A survival analysis of surgically treated incidental low-grade glioma patients
title_fullStr	A survival analysis of surgically treated incidental low-grade glioma patients
title_full_unstemmed	A survival analysis of surgically treated incidental low-grade glioma patients
title_sort	survival analysis of surgically treated incidental low-grade glioma patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d932271a0674da8adf47625cd56fc04
work_keys_str_mv	AT lingchengzeng asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT qimei asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT huali asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT changshuke asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT jiashengyu asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT jianchen asurvivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT lingchengzeng survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT qimei survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT huali survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT changshuke survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT jiashengyu survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients AT jianchen survivalanalysisofsurgicallytreatedincidentallowgradegliomapatients
_version_	1718383454972805120

A survival analysis of surgically treated incidental low-grade glioma patients

Ejemplares similares