Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response

Natural killer (NK) cells are known to be able to kill established tumor cell lines, but important caveats remain regarding their roles in the detection and elimination of developing primary tumors. Using a genetic model of selective ILC1 and NK cell deficiency, we showed that these cells were dispe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Margaux Vienne, Marion Etiennot, Bertrand Escalière, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	innate innate lymphoid cells (ILCs) antitumoral immunity NK cells ILC1 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5d93b170ef1f4e6eba648775277a2912
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d93b170ef1f4e6eba648775277a2912
record_format	dspace
spelling	oai:doaj.org-article:5d93b170ef1f4e6eba648775277a29122021-11-16T07:47:13ZType 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response1664-322410.3389/fimmu.2021.768989https://doaj.org/article/5d93b170ef1f4e6eba648775277a29122021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.768989/fullhttps://doaj.org/toc/1664-3224Natural killer (NK) cells are known to be able to kill established tumor cell lines, but important caveats remain regarding their roles in the detection and elimination of developing primary tumors. Using a genetic model of selective ILC1 and NK cell deficiency, we showed that these cells were dispensable for tumor immunosurveillance and immunoediting in the MCA-induced carcinogenesis model. However, we were able to generate primary cell lines derived from MCA-induced tumors with graded sensitivity to NK1.1+ cells (including NK cells and ILC1). This differential sensitivity was associated neither with a modulation of intratumoral NK cell frequency, nor the capacity of tumor cells to activate NK cells. Instead, ILC1 infiltration into the tumor was found to be a critical determinant of NK1.1+ cell-dependent tumor growth. Finally, bulk tumor RNAseq analysis identified a gene expression signature associated with tumor sensitivity to NK1.1+ cells. ILC1 therefore appear to play an active role in inhibiting the antitumoral immune response, prompting to evaluate the differential tumor infiltration of ILC1 and NK cells in patients to optimize the harnessing of immunity in cancer therapies.Margaux VienneMarion EtiennotBertrand EscalièreJustine GallusoLionel SpinelliSophie GuiaAurore FenisEric VivierEric VivierEric VivierYann M. KerdilesFrontiers Media S.A.articleinnateinnate lymphoid cells (ILCs)antitumoral immunityNK cellsILC1Immunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	innate innate lymphoid cells (ILCs) antitumoral immunity NK cells ILC1 Immunologic diseases. Allergy RC581-607
spellingShingle	innate innate lymphoid cells (ILCs) antitumoral immunity NK cells ILC1 Immunologic diseases. Allergy RC581-607 Margaux Vienne Marion Etiennot Bertrand Escalière Justine Galluso Lionel Spinelli Sophie Guia Aurore Fenis Eric Vivier Eric Vivier Eric Vivier Yann M. Kerdiles Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
description	Natural killer (NK) cells are known to be able to kill established tumor cell lines, but important caveats remain regarding their roles in the detection and elimination of developing primary tumors. Using a genetic model of selective ILC1 and NK cell deficiency, we showed that these cells were dispensable for tumor immunosurveillance and immunoediting in the MCA-induced carcinogenesis model. However, we were able to generate primary cell lines derived from MCA-induced tumors with graded sensitivity to NK1.1+ cells (including NK cells and ILC1). This differential sensitivity was associated neither with a modulation of intratumoral NK cell frequency, nor the capacity of tumor cells to activate NK cells. Instead, ILC1 infiltration into the tumor was found to be a critical determinant of NK1.1+ cell-dependent tumor growth. Finally, bulk tumor RNAseq analysis identified a gene expression signature associated with tumor sensitivity to NK1.1+ cells. ILC1 therefore appear to play an active role in inhibiting the antitumoral immune response, prompting to evaluate the differential tumor infiltration of ILC1 and NK cells in patients to optimize the harnessing of immunity in cancer therapies.
format	article
author	Margaux Vienne Marion Etiennot Bertrand Escalière Justine Galluso Lionel Spinelli Sophie Guia Aurore Fenis Eric Vivier Eric Vivier Eric Vivier Yann M. Kerdiles
author_facet	Margaux Vienne Marion Etiennot Bertrand Escalière Justine Galluso Lionel Spinelli Sophie Guia Aurore Fenis Eric Vivier Eric Vivier Eric Vivier Yann M. Kerdiles
author_sort	Margaux Vienne
title	Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
title_short	Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
title_full	Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
title_fullStr	Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
title_full_unstemmed	Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response
title_sort	type 1 innate lymphoid cells limit the antitumoral immune response
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d93b170ef1f4e6eba648775277a2912
work_keys_str_mv	AT margauxvienne type1innatelymphoidcellslimittheantitumoralimmuneresponse AT marionetiennot type1innatelymphoidcellslimittheantitumoralimmuneresponse AT bertrandescaliere type1innatelymphoidcellslimittheantitumoralimmuneresponse AT justinegalluso type1innatelymphoidcellslimittheantitumoralimmuneresponse AT lionelspinelli type1innatelymphoidcellslimittheantitumoralimmuneresponse AT sophieguia type1innatelymphoidcellslimittheantitumoralimmuneresponse AT aurorefenis type1innatelymphoidcellslimittheantitumoralimmuneresponse AT ericvivier type1innatelymphoidcellslimittheantitumoralimmuneresponse AT ericvivier type1innatelymphoidcellslimittheantitumoralimmuneresponse AT ericvivier type1innatelymphoidcellslimittheantitumoralimmuneresponse AT yannmkerdiles type1innatelymphoidcellslimittheantitumoralimmuneresponse
_version_	1718426605161807872

Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response

Ejemplares similares