Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele.

Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele.

Failure of elimination of amyloid-β (Aβ) from the brain and vasculature appears to be a key factor in the etiology of sporadic Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). In addition to age, possession of an apolipoprotein E (APOE) ε4 allele is a strong risk factor for the d...

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Main Authors: Cheryl A Hawkes, Patrick M Sullivan, Sarah Hands, Roy O Weller, James A R Nicoll, Roxana O Carare
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/5d95f3ca471547a880508f220d1f007f
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