Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)

Temam Beshir Raru,1 Bisrat Misganaw Geremew,2 Koku Sisay Tamirat2 1Department of Epidemiology and Biostatistics, School of Public Health, Haramaya University, Harar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, Universi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Raru TB, Geremew BM, Tamirat KS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	change in seizures frequency epilepsy antiepileptic drugs ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5d963c9007164c9f80669b496c17f512
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d963c9007164c9f80669b496c17f512
record_format	dspace
spelling	oai:doaj.org-article:5d963c9007164c9f80669b496c17f5122021-12-02T18:49:13ZChange in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)1178-2021https://doaj.org/article/5d963c9007164c9f80669b496c17f5122021-08-01T00:00:00Zhttps://www.dovepress.com/change-in-the-frequency-of-seizure-attacks-and-associated-factors-amon-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Temam Beshir Raru,1 Bisrat Misganaw Geremew,2 Koku Sisay Tamirat2 1Department of Epidemiology and Biostatistics, School of Public Health, Haramaya University, Harar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Temam Beshir Raru Email Temam.b1@gmail.comBackground: While getting anti-epileptic drugs (AEDs) treatment around two-thirds of the patients with epilepsy enter a seizure-free state, but some of them continue to experience seizures which increase the risk of accident, disability, death, and treatment side effects. Therefore, this study aimed to identifychanges in the frequency of seizure attacks overtime and associated factors among adult patients with epilepsy.Methods: A retrospective two year follow-up study was conducted among adult patients with epilepsy who initiated AEDs between July 2017 and June 2019. A simple random sampling technique was applied to select 394 patient charts. The data were entered into Epi-data and then exported to R software for further analysis. A generalized linear mixed model under a negative binomial family was applied to identify determinants of the frequency of seizure attacks.Results: The median number of seizure attacks at baseline were 3 with the IQR of 2 and on average the frequency of seizure attacks decrease in a linear pattern over time. Age group 25– 34 years (AIRR = 0.81 and 95% CI: 0.69– 0.94), smoking (AIRR = 1.28 and 95% CI: 1.11– 1.48), khat use (AIRR = 1.39 and 95% CI: 1.19– 1.62), sleep deprivation (AIRR = 1.49 and 95% CI: 1.32– 1.69), head injury (AIRR = 1.30 and 95% CI: 1.11– 1.53), depression (AIRR = 1.39 and 95% CI: 1.17– 1.65), treatment mode (AIRR= 1.22 and 95% CI: 1.07– 1.39), and clumsiness (AIRR= 1.85 and 95% CI: 1.24– 2.75) were statistically significant seizure predicting factors.Conclusion: The number of seizure attack changes over time was decreased by a linear function that might reflect treatment effects of AEDs. Smokers, khat chewers, suffering a head injury, depression, experienced sleep deprivation, and clumsiness increases the number of seizure attacks. Conversely, the age group 25– 34 years saw a decrease in the number of seizure attacks. This underscores that special attention should be given to substance users and those with related mental health disorders.Keywords: change in seizures frequency, epilepsy, anti-epileptic drugs, Ethiopia, AEDsRaru TBGeremew BMTamirat KSDove Medical Pressarticlechange in seizures frequencyepilepsyantiepileptic drugsethiopiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2529-2538 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	change in seizures frequency epilepsy antiepileptic drugs ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	change in seizures frequency epilepsy antiepileptic drugs ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Raru TB Geremew BM Tamirat KS Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
description	Temam Beshir Raru,1 Bisrat Misganaw Geremew,2 Koku Sisay Tamirat2 1Department of Epidemiology and Biostatistics, School of Public Health, Haramaya University, Harar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Temam Beshir Raru Email Temam.b1@gmail.comBackground: While getting anti-epileptic drugs (AEDs) treatment around two-thirds of the patients with epilepsy enter a seizure-free state, but some of them continue to experience seizures which increase the risk of accident, disability, death, and treatment side effects. Therefore, this study aimed to identifychanges in the frequency of seizure attacks overtime and associated factors among adult patients with epilepsy.Methods: A retrospective two year follow-up study was conducted among adult patients with epilepsy who initiated AEDs between July 2017 and June 2019. A simple random sampling technique was applied to select 394 patient charts. The data were entered into Epi-data and then exported to R software for further analysis. A generalized linear mixed model under a negative binomial family was applied to identify determinants of the frequency of seizure attacks.Results: The median number of seizure attacks at baseline were 3 with the IQR of 2 and on average the frequency of seizure attacks decrease in a linear pattern over time. Age group 25– 34 years (AIRR = 0.81 and 95% CI: 0.69– 0.94), smoking (AIRR = 1.28 and 95% CI: 1.11– 1.48), khat use (AIRR = 1.39 and 95% CI: 1.19– 1.62), sleep deprivation (AIRR = 1.49 and 95% CI: 1.32– 1.69), head injury (AIRR = 1.30 and 95% CI: 1.11– 1.53), depression (AIRR = 1.39 and 95% CI: 1.17– 1.65), treatment mode (AIRR= 1.22 and 95% CI: 1.07– 1.39), and clumsiness (AIRR= 1.85 and 95% CI: 1.24– 2.75) were statistically significant seizure predicting factors.Conclusion: The number of seizure attack changes over time was decreased by a linear function that might reflect treatment effects of AEDs. Smokers, khat chewers, suffering a head injury, depression, experienced sleep deprivation, and clumsiness increases the number of seizure attacks. Conversely, the age group 25– 34 years saw a decrease in the number of seizure attacks. This underscores that special attention should be given to substance users and those with related mental health disorders.Keywords: change in seizures frequency, epilepsy, anti-epileptic drugs, Ethiopia, AEDs
format	article
author	Raru TB Geremew BM Tamirat KS
author_facet	Raru TB Geremew BM Tamirat KS
author_sort	Raru TB
title	Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
title_short	Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
title_full	Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
title_fullStr	Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
title_full_unstemmed	Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)
title_sort	change in the frequency of seizure attacks and associated factors among adult epilepsy patients at amanuel mental specialized hospital (amsh): a generalized linear mixed model (glmm)
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5d963c9007164c9f80669b496c17f512
work_keys_str_mv	AT rarutb changeinthefrequencyofseizureattacksandassociatedfactorsamongadultepilepsypatientsatamanuelmentalspecializedhospitalamshageneralizedlinearmixedmodelglmm AT geremewbm changeinthefrequencyofseizureattacksandassociatedfactorsamongadultepilepsypatientsatamanuelmentalspecializedhospitalamshageneralizedlinearmixedmodelglmm AT tamiratks changeinthefrequencyofseizureattacksandassociatedfactorsamongadultepilepsypatientsatamanuelmentalspecializedhospitalamshageneralizedlinearmixedmodelglmm
_version_	1718377562236780544

Change in the Frequency of Seizure Attacks and Associated Factors Among Adult Epilepsy Patients at Amanuel Mental Specialized Hospital (AMSH): A Generalized Linear Mixed Model (GLMM)

Ejemplares similares