Synthetic RNA-based logic computation in mammalian cells

The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate an apoptosis-regulatory AND gate.

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Autores principales:	Satoshi Matsuura, Hiroki Ono, Shunsuke Kawasaki, Yi Kuang, Yoshihiko Fujita, Hirohide Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d96f4d949ff47c3bc906effbfc044f5
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spelling	oai:doaj.org-article:5d96f4d949ff47c3bc906effbfc044f52021-12-02T15:34:16ZSynthetic RNA-based logic computation in mammalian cells10.1038/s41467-018-07181-22041-1723https://doaj.org/article/5d96f4d949ff47c3bc906effbfc044f52018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07181-2https://doaj.org/toc/2041-1723The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate an apoptosis-regulatory AND gate.Satoshi MatsuuraHiroki OnoShunsuke KawasakiYi KuangYoshihiko FujitaHirohide SaitoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Matsuura Hiroki Ono Shunsuke Kawasaki Yi Kuang Yoshihiko Fujita Hirohide Saito Synthetic RNA-based logic computation in mammalian cells
description	The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use. Here the authors construct a set of logic gates that respond to multiple miRNAs and demonstrate an apoptosis-regulatory AND gate.
format	article
author	Satoshi Matsuura Hiroki Ono Shunsuke Kawasaki Yi Kuang Yoshihiko Fujita Hirohide Saito
author_facet	Satoshi Matsuura Hiroki Ono Shunsuke Kawasaki Yi Kuang Yoshihiko Fujita Hirohide Saito
author_sort	Satoshi Matsuura
title	Synthetic RNA-based logic computation in mammalian cells
title_short	Synthetic RNA-based logic computation in mammalian cells
title_full	Synthetic RNA-based logic computation in mammalian cells
title_fullStr	Synthetic RNA-based logic computation in mammalian cells
title_full_unstemmed	Synthetic RNA-based logic computation in mammalian cells
title_sort	synthetic rna-based logic computation in mammalian cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5d96f4d949ff47c3bc906effbfc044f5
work_keys_str_mv	AT satoshimatsuura syntheticrnabasedlogiccomputationinmammaliancells AT hirokiono syntheticrnabasedlogiccomputationinmammaliancells AT shunsukekawasaki syntheticrnabasedlogiccomputationinmammaliancells AT yikuang syntheticrnabasedlogiccomputationinmammaliancells AT yoshihikofujita syntheticrnabasedlogiccomputationinmammaliancells AT hirohidesaito syntheticrnabasedlogiccomputationinmammaliancells
_version_	1718386901307621376

Synthetic RNA-based logic computation in mammalian cells

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