Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development...

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Autores principales:	Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y. Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, Daniel Taliun, Matthias Olden, Meredith Foster, Qiong Yang, Ming-Huei Chen, Tune H. Pers, Andrew D. Johnson, Yi-An Ko, Christian Fuchsberger, Bamidele Tayo, Michael Nalls, Mary F. Feitosa, Aaron Isaacs, Abbas Dehghan, Pio d’Adamo, Adebowale Adeyemo, Aida Karina Dieffenbach, Alan B. Zonderman, Ilja M. Nolte, Peter J. van der Most, Alan F. Wright, Alan R. Shuldiner, Alanna C. Morrison, Albert Hofman, Albert V. Smith, Albert W. Dreisbach, Andre Franke, Andre G. Uitterlinden, Andres Metspalu, Anke Tonjes, Antonio Lupo, Antonietta Robino, Åsa Johansson, Ayse Demirkan, Barbara Kollerits, Barry I. Freedman, Belen Ponte, Ben A. Oostra, Bernhard Paulweber, Bernhard K. Krämer, Braxton D. Mitchell, Brendan M. Buckley, Carmen A. Peralta, Caroline Hayward, Catherine Helmer, Charles N. Rotimi, Christian M. Shaffer, Christian Müller, Cinzia Sala, Cornelia M. van Duijn, Aude Saint-Pierre, Daniel Ackermann, Daniel Shriner, Daniela Ruggiero, Daniela Toniolo, Yingchang Lu, Daniele Cusi, Darina Czamara, David Ellinghaus, David S. Siscovick, Douglas Ruderfer, Christian Gieger, Harald Grallert, Elena Rochtchina, Elizabeth J. Atkinson, Elizabeth G. Holliday, Eric Boerwinkle, Erika Salvi, Erwin P. Bottinger, Federico Murgia, Fernando Rivadeneira, Florian Ernst, Florian Kronenberg, Frank B. Hu, Gerjan J. Navis, Gary C. Curhan, George B. Ehret, Georg Homuth, Stefan Coassin, Gian-Andri Thun, Giorgio Pistis, Giovanni Gambaro, Giovanni Malerba, Grant W. Montgomery, Gudny Eiriksdottir, Gunnar Jacobs, Guo Li, H-Erich Wichmann, Harry Campbell, Helena Schmidt, Henri Wallaschofski, Henry Völzke, Hermann Brenner, Heyo K. Kroemer, Holly Kramer, Honghuang Lin, I. Mateo Leach, Ian Ford, Idris Guessous, Igor Rudan, Inga Prokopenko, Ingrid Borecki, Iris M. Heid, Ivana Kolcic, Ivana Persico, J. Wouter Jukema, James F. Wilson, Janine F. Felix, Jasmin Divers, Jean-Charles Lambert, Jeanette M. Stafford, Jean-Michel Gaspoz, Jennifer A. Smith, Jessica D. Faul, Jie Jin Wang, Jingzhong Ding, Joel N. Hirschhorn, John Attia, John B. Whitfield, John Chalmers, Jorma Viikari, Josef Coresh, Joshua C. Denny, Juha Karjalainen, Jyotika K. Fernandes, Karlhans Endlich, Katja Butterbach, Keith L. Keene, Kurt Lohman, Laura Portas, Lenore J. Launer, Leo-Pekka Lyytikäinen, Loic Yengo, Lude Franke, Luigi Ferrucci, Lynda M. Rose, Lyudmyla Kedenko, Madhumathi Rao, Maksim Struchalin, Marcus E. Kleber, Margherita Cavalieri, Margot Haun, Marilyn C. Cornelis, Marina Ciullo, Mario Pirastu, Mariza de Andrade, Mark A. McEvoy, Mark Woodward, Martin Adam, Massimiliano Cocca, Matthias Nauck, Medea Imboden, Melanie Waldenberger, Menno Pruijm, Marie Metzger, Michael Stumvoll, Michele K. Evans, Michele M. Sale, Mika Kähönen, Mladen Boban, Murielle Bochud, Myriam Rheinberger, Niek Verweij, Nabila Bouatia-Naji, Nicholas G. Martin, Nick Hastie, Nicole Probst-Hensch, Nicole Soranzo, Olivier Devuyst, Olli Raitakari, Omri Gottesman, Oscar H. Franco, Ozren Polasek, Paolo Gasparini, Patricia B. Munroe, Paul M. Ridker, Paul Mitchell, Paul Muntner, Christa Meisinger, Johannes H. Smit, ICBP Consortium, AGEN Consortium, CARDIOGRAM, CHARGe-Heart Failure Group, ECHOGen Consortium, Peter Kovacs, Philipp S. Wild, Philippe Froguel, Rainer Rettig, Reedik Mägi, Reiner Biffar, Reinhold Schmidt, Rita P. S. Middelberg, Robert J. Carroll, Brenda W. Penninx, Rodney J. Scott, Ronit Katz, Sanaz Sedaghat, Sarah H. Wild, Sharon L. R. Kardia, Sheila Ulivi, Shih-Jen Hwang, Stefan Enroth, Stefan Kloiber, Stella Trompet, Benedicte Stengel, Stephen J. Hancock, Stephen T. Turner, Sylvia E. Rosas, Sylvia Stracke, Tamara B. Harris, Tanja Zeller, Tatijana Zemunik, Terho Lehtimäki, Thomas Illig, Thor Aspelund, Tiit Nikopensius, Tonu Esko, Toshiko Tanaka, Ulf Gyllensten, Uwe Völker, Valur Emilsson, Veronique Vitart, Ville Aalto, Vilmundur Gudnason, Vincent Chouraki, Wei-Min Chen, Wilmar Igl, Winfried März, Wolfgang Koenig, Wolfgang Lieb, Ruth J. F. Loos, Yongmei Liu, Harold Snieder, Peter P. Pramstaller, Afshin Parsa, Jeffrey R. O’Connell, Katalin Susztak, Pavel Hamet, Johanne Tremblay, Ian H. de Boer, Carsten A. Böger, Wolfram Goessling, Daniel I. Chasman, Anna Köttgen, W. H. Linda Kao, Caroline S. Fox
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d9d63e116c24c36a1c1be4822c2160b
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record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y. Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H. Pers Andrew D. Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F. Feitosa Aaron Isaacs Abbas Dehghan Pio d’Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B. Zonderman Ilja M. Nolte Peter J. van der Most Alan F. Wright Alan R. Shuldiner Alanna C. Morrison Albert Hofman Albert V. Smith Albert W. Dreisbach Andre Franke Andre G. Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I. Freedman Belen Ponte Ben A. Oostra Bernhard Paulweber Bernhard K. Krämer Braxton D. Mitchell Brendan M. Buckley Carmen A. Peralta Caroline Hayward Catherine Helmer Charles N. Rotimi Christian M. Shaffer Christian Müller Cinzia Sala Cornelia M. van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S. Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J. Atkinson Elizabeth G. Holliday Eric Boerwinkle Erika Salvi Erwin P. Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B. Hu Gerjan J. Navis Gary C. Curhan George B. Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W. Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K. Kroemer Holly Kramer Honghuang Lin I. Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M. Heid Ivana Kolcic Ivana Persico J. Wouter Jukema James F. Wilson Janine F. Felix Jasmin Divers Jean-Charles Lambert Jeanette M. Stafford Jean-Michel Gaspoz Jennifer A. Smith Jessica D. Faul Jie Jin Wang Jingzhong Ding Joel N. Hirschhorn John Attia John B. Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C. Denny Juha Karjalainen Jyotika K. Fernandes Karlhans Endlich Katja Butterbach Keith L. Keene Kurt Lohman Laura Portas Lenore J. Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M. Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E. Kleber Margherita Cavalieri Margot Haun Marilyn C. Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A. McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K. Evans Michele M. Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G. Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H. Franco Ozren Polasek Paolo Gasparini Patricia B. Munroe Paul M. Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H. Smit ICBP Consortium AGEN Consortium CARDIOGRAM CHARGe-Heart Failure Group ECHOGen Consortium Peter Kovacs Philipp S. Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P. S. Middelberg Robert J. Carroll Brenda W. Penninx Rodney J. Scott Ronit Katz Sanaz Sedaghat Sarah H. Wild Sharon L. R. Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J. Hancock Stephen T. Turner Sylvia E. Rosas Sylvia Stracke Tamara B. Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J. F. Loos Yongmei Liu Harold Snieder Peter P. Pramstaller Afshin Parsa Jeffrey R. O’Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H. de Boer Carsten A. Böger Wolfram Goessling Daniel I. Chasman Anna Köttgen W. H. Linda Kao Caroline S. Fox Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
description	Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.
format	article
author	Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y. Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H. Pers Andrew D. Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F. Feitosa Aaron Isaacs Abbas Dehghan Pio d’Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B. Zonderman Ilja M. Nolte Peter J. van der Most Alan F. Wright Alan R. Shuldiner Alanna C. Morrison Albert Hofman Albert V. Smith Albert W. Dreisbach Andre Franke Andre G. Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I. Freedman Belen Ponte Ben A. Oostra Bernhard Paulweber Bernhard K. Krämer Braxton D. Mitchell Brendan M. Buckley Carmen A. Peralta Caroline Hayward Catherine Helmer Charles N. Rotimi Christian M. Shaffer Christian Müller Cinzia Sala Cornelia M. van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S. Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J. Atkinson Elizabeth G. Holliday Eric Boerwinkle Erika Salvi Erwin P. Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B. Hu Gerjan J. Navis Gary C. Curhan George B. Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W. Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K. Kroemer Holly Kramer Honghuang Lin I. Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M. Heid Ivana Kolcic Ivana Persico J. Wouter Jukema James F. Wilson Janine F. Felix Jasmin Divers Jean-Charles Lambert Jeanette M. Stafford Jean-Michel Gaspoz Jennifer A. Smith Jessica D. Faul Jie Jin Wang Jingzhong Ding Joel N. Hirschhorn John Attia John B. Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C. Denny Juha Karjalainen Jyotika K. Fernandes Karlhans Endlich Katja Butterbach Keith L. Keene Kurt Lohman Laura Portas Lenore J. Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M. Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E. Kleber Margherita Cavalieri Margot Haun Marilyn C. Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A. McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K. Evans Michele M. Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G. Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H. Franco Ozren Polasek Paolo Gasparini Patricia B. Munroe Paul M. Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H. Smit ICBP Consortium AGEN Consortium CARDIOGRAM CHARGe-Heart Failure Group ECHOGen Consortium Peter Kovacs Philipp S. Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P. S. Middelberg Robert J. Carroll Brenda W. Penninx Rodney J. Scott Ronit Katz Sanaz Sedaghat Sarah H. Wild Sharon L. R. Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J. Hancock Stephen T. Turner Sylvia E. Rosas Sylvia Stracke Tamara B. Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J. F. Loos Yongmei Liu Harold Snieder Peter P. Pramstaller Afshin Parsa Jeffrey R. O’Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H. de Boer Carsten A. Böger Wolfram Goessling Daniel I. Chasman Anna Köttgen W. H. Linda Kao Caroline S. Fox
author_facet	Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y. Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H. Pers Andrew D. Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F. Feitosa Aaron Isaacs Abbas Dehghan Pio d’Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B. Zonderman Ilja M. Nolte Peter J. van der Most Alan F. Wright Alan R. Shuldiner Alanna C. Morrison Albert Hofman Albert V. Smith Albert W. Dreisbach Andre Franke Andre G. Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I. Freedman Belen Ponte Ben A. Oostra Bernhard Paulweber Bernhard K. Krämer Braxton D. Mitchell Brendan M. Buckley Carmen A. Peralta Caroline Hayward Catherine Helmer Charles N. Rotimi Christian M. Shaffer Christian Müller Cinzia Sala Cornelia M. van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S. Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J. Atkinson Elizabeth G. Holliday Eric Boerwinkle Erika Salvi Erwin P. Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B. Hu Gerjan J. Navis Gary C. Curhan George B. Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W. Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K. Kroemer Holly Kramer Honghuang Lin I. Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M. Heid Ivana Kolcic Ivana Persico J. Wouter Jukema James F. Wilson Janine F. Felix Jasmin Divers Jean-Charles Lambert Jeanette M. Stafford Jean-Michel Gaspoz Jennifer A. Smith Jessica D. Faul Jie Jin Wang Jingzhong Ding Joel N. Hirschhorn John Attia John B. Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C. Denny Juha Karjalainen Jyotika K. Fernandes Karlhans Endlich Katja Butterbach Keith L. Keene Kurt Lohman Laura Portas Lenore J. Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M. Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E. Kleber Margherita Cavalieri Margot Haun Marilyn C. Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A. McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K. Evans Michele M. Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G. Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H. Franco Ozren Polasek Paolo Gasparini Patricia B. Munroe Paul M. Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H. Smit ICBP Consortium AGEN Consortium CARDIOGRAM CHARGe-Heart Failure Group ECHOGen Consortium Peter Kovacs Philipp S. Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P. S. Middelberg Robert J. Carroll Brenda W. Penninx Rodney J. Scott Ronit Katz Sanaz Sedaghat Sarah H. Wild Sharon L. R. Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J. Hancock Stephen T. Turner Sylvia E. Rosas Sylvia Stracke Tamara B. Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J. F. Loos Yongmei Liu Harold Snieder Peter P. Pramstaller Afshin Parsa Jeffrey R. O’Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H. de Boer Carsten A. Böger Wolfram Goessling Daniel I. Chasman Anna Köttgen W. H. Linda Kao Caroline S. Fox
author_sort	Cristian Pattaro
title	Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
title_short	Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
title_full	Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
title_fullStr	Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
title_full_unstemmed	Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
title_sort	genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5d9d63e116c24c36a1c1be4822c2160b
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spelling	oai:doaj.org-article:5d9d63e116c24c36a1c1be4822c2160b2021-12-02T17:31:17ZGenetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function10.1038/ncomms100232041-1723https://doaj.org/article/5d9d63e116c24c36a1c1be4822c2160b2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10023https://doaj.org/toc/2041-1723Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode proteins potentially related to kidney development.Cristian PattaroAlexander TeumerMathias GorskiAudrey Y. ChuMan LiVladan MijatovicMaija GarnaasAdrienne TinRossella SoriceYong LiDaniel TaliunMatthias OldenMeredith FosterQiong YangMing-Huei ChenTune H. PersAndrew D. JohnsonYi-An KoChristian FuchsbergerBamidele TayoMichael NallsMary F. FeitosaAaron IsaacsAbbas DehghanPio d’AdamoAdebowale AdeyemoAida Karina DieffenbachAlan B. ZondermanIlja M. NoltePeter J. van der MostAlan F. WrightAlan R. ShuldinerAlanna C. MorrisonAlbert HofmanAlbert V. SmithAlbert W. DreisbachAndre FrankeAndre G. UitterlindenAndres MetspaluAnke TonjesAntonio LupoAntonietta RobinoÅsa JohanssonAyse DemirkanBarbara KolleritsBarry I. FreedmanBelen PonteBen A. OostraBernhard PaulweberBernhard K. KrämerBraxton D. MitchellBrendan M. BuckleyCarmen A. PeraltaCaroline HaywardCatherine HelmerCharles N. RotimiChristian M. ShafferChristian MüllerCinzia SalaCornelia M. van DuijnAude Saint-PierreDaniel AckermannDaniel ShrinerDaniela RuggieroDaniela TonioloYingchang LuDaniele CusiDarina CzamaraDavid EllinghausDavid S. SiscovickDouglas RuderferChristian GiegerHarald GrallertElena RochtchinaElizabeth J. AtkinsonElizabeth G. HollidayEric BoerwinkleErika SalviErwin P. BottingerFederico MurgiaFernando RivadeneiraFlorian ErnstFlorian KronenbergFrank B. HuGerjan J. NavisGary C. CurhanGeorge B. EhretGeorg HomuthStefan CoassinGian-Andri ThunGiorgio PistisGiovanni GambaroGiovanni MalerbaGrant W. MontgomeryGudny EiriksdottirGunnar JacobsGuo LiH-Erich WichmannHarry CampbellHelena SchmidtHenri WallaschofskiHenry VölzkeHermann BrennerHeyo K. KroemerHolly KramerHonghuang LinI. Mateo LeachIan FordIdris GuessousIgor RudanInga ProkopenkoIngrid BoreckiIris M. HeidIvana KolcicIvana PersicoJ. Wouter JukemaJames F. WilsonJanine F. FelixJasmin DiversJean-Charles LambertJeanette M. StaffordJean-Michel GaspozJennifer A. SmithJessica D. FaulJie Jin WangJingzhong DingJoel N. HirschhornJohn AttiaJohn B. WhitfieldJohn ChalmersJorma ViikariJosef CoreshJoshua C. DennyJuha KarjalainenJyotika K. FernandesKarlhans EndlichKatja ButterbachKeith L. KeeneKurt LohmanLaura PortasLenore J. LaunerLeo-Pekka LyytikäinenLoic YengoLude FrankeLuigi FerrucciLynda M. RoseLyudmyla KedenkoMadhumathi RaoMaksim StruchalinMarcus E. KleberMargherita CavalieriMargot HaunMarilyn C. CornelisMarina CiulloMario PirastuMariza de AndradeMark A. McEvoyMark WoodwardMartin AdamMassimiliano CoccaMatthias NauckMedea ImbodenMelanie WaldenbergerMenno PruijmMarie MetzgerMichael StumvollMichele K. EvansMichele M. SaleMika KähönenMladen BobanMurielle BochudMyriam RheinbergerNiek VerweijNabila Bouatia-NajiNicholas G. MartinNick HastieNicole Probst-HenschNicole SoranzoOlivier DevuystOlli RaitakariOmri GottesmanOscar H. FrancoOzren PolasekPaolo GaspariniPatricia B. MunroePaul M. RidkerPaul MitchellPaul MuntnerChrista MeisingerJohannes H. SmitICBP ConsortiumAGEN ConsortiumCARDIOGRAMCHARGe-Heart Failure GroupECHOGen ConsortiumPeter KovacsPhilipp S. WildPhilippe FroguelRainer RettigReedik MägiReiner BiffarReinhold SchmidtRita P. S. MiddelbergRobert J. CarrollBrenda W. PenninxRodney J. ScottRonit KatzSanaz SedaghatSarah H. WildSharon L. R. KardiaSheila UliviShih-Jen HwangStefan EnrothStefan KloiberStella TrompetBenedicte StengelStephen J. HancockStephen T. TurnerSylvia E. RosasSylvia StrackeTamara B. HarrisTanja ZellerTatijana ZemunikTerho LehtimäkiThomas IlligThor AspelundTiit NikopensiusTonu EskoToshiko TanakaUlf GyllenstenUwe VölkerValur EmilssonVeronique VitartVille AaltoVilmundur GudnasonVincent ChourakiWei-Min ChenWilmar IglWinfried MärzWolfgang KoenigWolfgang LiebRuth J. F. LoosYongmei LiuHarold SniederPeter P. PramstallerAfshin ParsaJeffrey R. O’ConnellKatalin SusztakPavel HametJohanne TremblayIan H. de BoerCarsten A. BögerWolfram GoesslingDaniel I. ChasmanAnna KöttgenW. H. Linda KaoCaroline S. FoxNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

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