Structure-mediated modulation of mRNA abundance by A-to-I editing

Structure-mediated modulation of mRNA abundance by A-to-I editing

RNA A-to-I editing introduces single nucleotide changes to RNA, but its role in cells remains unclear. Here, the authors analyse A-to-I editomes in human samples and find that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs.

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Autores principales: Anneke Brümmer, Yun Yang, Tracey W. Chan, Xinshu Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5d9efa5f2b0f407eb13258b55e3e104b
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spelling oai:doaj.org-article:5d9efa5f2b0f407eb13258b55e3e104b2021-12-02T17:06:14ZStructure-mediated modulation of mRNA abundance by A-to-I editing10.1038/s41467-017-01459-72041-1723https://doaj.org/article/5d9efa5f2b0f407eb13258b55e3e104b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01459-7https://doaj.org/toc/2041-1723RNA A-to-I editing introduces single nucleotide changes to RNA, but its role in cells remains unclear. Here, the authors analyse A-to-I editomes in human samples and find that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs.Anneke BrümmerYun YangTracey W. ChanXinshu XiaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anneke Brümmer
Yun Yang
Tracey W. Chan
Xinshu Xiao
Structure-mediated modulation of mRNA abundance by A-to-I editing
description RNA A-to-I editing introduces single nucleotide changes to RNA, but its role in cells remains unclear. Here, the authors analyse A-to-I editomes in human samples and find that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs.
format article
author Anneke Brümmer
Yun Yang
Tracey W. Chan
Xinshu Xiao
author_facet Anneke Brümmer
Yun Yang
Tracey W. Chan
Xinshu Xiao
author_sort Anneke Brümmer
title Structure-mediated modulation of mRNA abundance by A-to-I editing
title_short Structure-mediated modulation of mRNA abundance by A-to-I editing
title_full Structure-mediated modulation of mRNA abundance by A-to-I editing
title_fullStr Structure-mediated modulation of mRNA abundance by A-to-I editing
title_full_unstemmed Structure-mediated modulation of mRNA abundance by A-to-I editing
title_sort structure-mediated modulation of mrna abundance by a-to-i editing
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/5d9efa5f2b0f407eb13258b55e3e104b
work_keys_str_mv AT annekebrummer structuremediatedmodulationofmrnaabundancebyatoiediting
AT yunyang structuremediatedmodulationofmrnaabundancebyatoiediting
AT traceywchan structuremediatedmodulationofmrnaabundancebyatoiediting
AT xinshuxiao structuremediatedmodulationofmrnaabundancebyatoiediting
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