Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats

Introduction Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protecti...

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Autores principales:	Mehmet Ali Erdogan, Alper Yalcin
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	irisin liver toxicity benfotiamine oxidative stress rats Medicine R
Acceso en línea:	https://doaj.org/article/5da203d1c88d4527ad0775cdb99de6c9
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spelling	oai:doaj.org-article:5da203d1c88d4527ad0775cdb99de6c92021-12-02T18:39:22ZProtective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats1734-19221896-915110.5114/aoms.2018.80002https://doaj.org/article/5da203d1c88d4527ad0775cdb99de6c92019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Protective-effects-of-benfotiamine-on-irisin-activity-in-methotrexate-induced-liver,99247,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity. Material and methods Rats were divided into 4 groups as follows: control, benfotiamine (50 mg/kg, oral gavage (o.g.), for 14 days), MTX (MTX 20 mg/kg intraperitoneally (i.p.) on day 1), MTX + benfotiamine (MTX 20 mg/kg (i.p.) on day 1, then 50 mg/kg (o.g.) benfotiamine for 14 days). Liver tissue was used to examine histopathological and immunohistochemical changes. Serum was used to look for oxidative stress markers (total antioxidant status (TAS) and total oxidant status (TOS)). Results Administration of MTX caused a significant TOS increase and TAS decrease in the serum as compared to the control group. Immunohistochemically, irisin was significantly increased in immunoreactivity in the MTX group as compared to the control group (p < 0.05). Significant histopathological improvement and decrease in serum TOS levels were observed in the MTX + benfotiamine group compared to the MTX group (p 0.05). Conclusions Our results showed that MTX caused an increase in the activity of irisin after producing toxicity in the liver. In addition, we found that benfotiamine was effective in preventing damage caused by MTX in the liver.Mehmet Ali ErdoganAlper YalcinTermedia Publishing Housearticleirisinliver toxicitybenfotiamineoxidative stressratsMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 205-211 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	irisin liver toxicity benfotiamine oxidative stress rats Medicine R
spellingShingle	irisin liver toxicity benfotiamine oxidative stress rats Medicine R Mehmet Ali Erdogan Alper Yalcin Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
description	Introduction Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity. Material and methods Rats were divided into 4 groups as follows: control, benfotiamine (50 mg/kg, oral gavage (o.g.), for 14 days), MTX (MTX 20 mg/kg intraperitoneally (i.p.) on day 1), MTX + benfotiamine (MTX 20 mg/kg (i.p.) on day 1, then 50 mg/kg (o.g.) benfotiamine for 14 days). Liver tissue was used to examine histopathological and immunohistochemical changes. Serum was used to look for oxidative stress markers (total antioxidant status (TAS) and total oxidant status (TOS)). Results Administration of MTX caused a significant TOS increase and TAS decrease in the serum as compared to the control group. Immunohistochemically, irisin was significantly increased in immunoreactivity in the MTX group as compared to the control group (p < 0.05). Significant histopathological improvement and decrease in serum TOS levels were observed in the MTX + benfotiamine group compared to the MTX group (p 0.05). Conclusions Our results showed that MTX caused an increase in the activity of irisin after producing toxicity in the liver. In addition, we found that benfotiamine was effective in preventing damage caused by MTX in the liver.
format	article
author	Mehmet Ali Erdogan Alper Yalcin
author_facet	Mehmet Ali Erdogan Alper Yalcin
author_sort	Mehmet Ali Erdogan
title	Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
title_short	Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
title_full	Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
title_fullStr	Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
title_full_unstemmed	Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
title_sort	protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/5da203d1c88d4527ad0775cdb99de6c9
work_keys_str_mv	AT mehmetalierdogan protectiveeffectsofbenfotiamineonirisinactivityinmethotrexateinducedliverinjuryinrats AT alperyalcin protectiveeffectsofbenfotiamineonirisinactivityinmethotrexateinducedliverinjuryinrats
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Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats

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