Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report

Abstract Background The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone me...

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Autores principales:	Yasaman Fakhar, Alireza Khooei, Atena Aghaee, Hadis Mohammadzadeh Kosari, Leonard Wartofsky, Seyed Rasoul Zakavi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	NIFTP Bone metastasis Thyroid cancer Thyroglobulin Case report Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5da884a564164a8bbbcb42b3a2ea2928
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spelling	oai:doaj.org-article:5da884a564164a8bbbcb42b3a2ea29282021-11-07T12:02:16ZBone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report10.1186/s12902-021-00883-71472-6823https://doaj.org/article/5da884a564164a8bbbcb42b3a2ea29282021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00883-7https://doaj.org/toc/1472-6823Abstract Background The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far. Case presentation We describe a 38-year-old woman who presented with an indeterminate thyroid nodule and underwent total thyroidectomy with the finding of NIFTP on careful pathologic examination. However, her initial follow-up evaluation revealed a serum thyroglobulin level of > 300 ng/ml and a diagnostic whole body 131I scan demonstrated a focus of increased uptake in the left hemipelvis, confirmed on CT scan to be a lytic lesion in the left iliac bone. She was treated with 7.4GBq (200 mCi) of 131I and her follow-up 1 year later revealed an undetectable serum thyroglobulin and a negative whole body 131I scan with no visible uptake in the iliac bone indicating an excellent response. Conclusion This case presentation reminds us to be alert to the rare occurrence of distant metastasis in NIFTP and the need for a case by case analysis and continuing post-operative follow-up for detection of residual or recurrent disease.Yasaman FakharAlireza KhooeiAtena AghaeeHadis Mohammadzadeh KosariLeonard WartofskySeyed Rasoul ZakaviBMCarticleNIFTPBone metastasisThyroid cancerThyroglobulinCase reportDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NIFTP Bone metastasis Thyroid cancer Thyroglobulin Case report Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	NIFTP Bone metastasis Thyroid cancer Thyroglobulin Case report Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yasaman Fakhar Alireza Khooei Atena Aghaee Hadis Mohammadzadeh Kosari Leonard Wartofsky Seyed Rasoul Zakavi Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
description	Abstract Background The term non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was recently proposed as a non-malignant thyroid lesion with indolent behavior that does not require post-operative radio-iodine treatment. We are reporting a case of NIFTP with bone metastasis that is the second case reported so far. Case presentation We describe a 38-year-old woman who presented with an indeterminate thyroid nodule and underwent total thyroidectomy with the finding of NIFTP on careful pathologic examination. However, her initial follow-up evaluation revealed a serum thyroglobulin level of > 300 ng/ml and a diagnostic whole body 131I scan demonstrated a focus of increased uptake in the left hemipelvis, confirmed on CT scan to be a lytic lesion in the left iliac bone. She was treated with 7.4GBq (200 mCi) of 131I and her follow-up 1 year later revealed an undetectable serum thyroglobulin and a negative whole body 131I scan with no visible uptake in the iliac bone indicating an excellent response. Conclusion This case presentation reminds us to be alert to the rare occurrence of distant metastasis in NIFTP and the need for a case by case analysis and continuing post-operative follow-up for detection of residual or recurrent disease.
format	article
author	Yasaman Fakhar Alireza Khooei Atena Aghaee Hadis Mohammadzadeh Kosari Leonard Wartofsky Seyed Rasoul Zakavi
author_facet	Yasaman Fakhar Alireza Khooei Atena Aghaee Hadis Mohammadzadeh Kosari Leonard Wartofsky Seyed Rasoul Zakavi
author_sort	Yasaman Fakhar
title	Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
title_short	Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
title_full	Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
title_fullStr	Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
title_full_unstemmed	Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report
title_sort	bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (niftp); a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5da884a564164a8bbbcb42b3a2ea2928
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Bone metastasis from noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP); a case report

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