Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. Materials and methods: C57BL/6N mice were divided into four groups...

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Autores principales:	Keun-Hyeun Lee, Dabin Choi, Seung-Il Jeong, Sang-Jun Kim, Chang Hyun Lee, Hyung-Sik Seo, Han-Sol Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	hair follicular cycle human dermal papilla mtor Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5daa1b2f19d74848ae55d0a3c6b90f63
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spelling	oai:doaj.org-article:5daa1b2f19d74848ae55d0a3c6b90f632021-11-17T14:21:55ZEclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-51388-02091744-511610.1080/13880209.2018.1561729https://doaj.org/article/5daa1b2f19d74848ae55d0a3c6b90f632019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1561729https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. Materials and methods: C57BL/6N mice were divided into four groups (n = 4) as follows: control (topical treatment of normal saline), topical 3% minoxidil to the dorsal skin of mice for 14 days, and low (1 mg/day) and high (10 mg/day) doses of EP orally administered once a day for 14 days. Dorsal hairs of C57BL/6N mice were depilated to synchronize anagen induction. Hair growth activity was evaluated by gross and microscopic observations. Sections of dorsal skin were stained with haematoxylin and eosin. We also treated the various concentrations of EP (5, 10 and 50 μg/mL) for 24 h on the human dermal papilla cells (HDPs) and examined the effects of EP on the expression of FGF-7 and mTOR signalling. Results: EP enhanced the induction of anagen in the dorsal skin of mice, characterized by the appearance of inner root sheath along with hair shaft, the emergence of hair shaft through the epidermis. EP increased the expression of FGF-7, while decreased the level of FGF-5 in C57/BL6 mice. EP also increased the expression of FGF-7, activated the mTOR signalling in HDPs. Discussion and conclusions: These results suggest that EP has a potency to enhance the growth of hair follicle, promoting hair growth through regulation of FGF-7 and FGF-5.Keun-Hyeun LeeDabin ChoiSeung-Il JeongSang-Jun KimChang Hyun LeeHyung-Sik SeoHan-Sol JeongTaylor & Francis Grouparticlehair follicular cyclehuman dermal papillamtorTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 105-111 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	hair follicular cycle human dermal papilla mtor Therapeutics. Pharmacology RM1-950
spellingShingle	hair follicular cycle human dermal papilla mtor Therapeutics. Pharmacology RM1-950 Keun-Hyeun Lee Dabin Choi Seung-Il Jeong Sang-Jun Kim Chang Hyun Lee Hyung-Sik Seo Han-Sol Jeong Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
description	Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro. Materials and methods: C57BL/6N mice were divided into four groups (n = 4) as follows: control (topical treatment of normal saline), topical 3% minoxidil to the dorsal skin of mice for 14 days, and low (1 mg/day) and high (10 mg/day) doses of EP orally administered once a day for 14 days. Dorsal hairs of C57BL/6N mice were depilated to synchronize anagen induction. Hair growth activity was evaluated by gross and microscopic observations. Sections of dorsal skin were stained with haematoxylin and eosin. We also treated the various concentrations of EP (5, 10 and 50 μg/mL) for 24 h on the human dermal papilla cells (HDPs) and examined the effects of EP on the expression of FGF-7 and mTOR signalling. Results: EP enhanced the induction of anagen in the dorsal skin of mice, characterized by the appearance of inner root sheath along with hair shaft, the emergence of hair shaft through the epidermis. EP increased the expression of FGF-7, while decreased the level of FGF-5 in C57/BL6 mice. EP also increased the expression of FGF-7, activated the mTOR signalling in HDPs. Discussion and conclusions: These results suggest that EP has a potency to enhance the growth of hair follicle, promoting hair growth through regulation of FGF-7 and FGF-5.
format	article
author	Keun-Hyeun Lee Dabin Choi Seung-Il Jeong Sang-Jun Kim Chang Hyun Lee Hyung-Sik Seo Han-Sol Jeong
author_facet	Keun-Hyeun Lee Dabin Choi Seung-Il Jeong Sang-Jun Kim Chang Hyun Lee Hyung-Sik Seo Han-Sol Jeong
author_sort	Keun-Hyeun Lee
title	Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
title_short	Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
title_full	Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
title_fullStr	Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
title_full_unstemmed	Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
title_sort	eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of fgf-7 and fgf-5
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/5daa1b2f19d74848ae55d0a3c6b90f63
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Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

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