NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

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Autores principales:	Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5daa48a82f9b456488d8d66573ddc116
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spelling	oai:doaj.org-article:5daa48a82f9b456488d8d66573ddc1162021-12-02T17:31:51ZNLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions10.1038/ncomms105542041-1723https://doaj.org/article/5daa48a82f9b456488d8d66573ddc1162016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10554https://doaj.org/toc/2041-1723NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.Kristina LudigsCamilla JandusDaniel T. UtzschneiderFrancesco StaehliStéphanie BessolesAnh Thu DangGiorgia RotaWilson CastroDietmar ZehnEric VivierWerner HeldPedro RomeroGreta GuardaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
description	NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.
format	article
author	Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda
author_facet	Kristina Ludigs Camilla Jandus Daniel T. Utzschneider Francesco Staehli Stéphanie Bessoles Anh Thu Dang Giorgia Rota Wilson Castro Dietmar Zehn Eric Vivier Werner Held Pedro Romero Greta Guarda
author_sort	Kristina Ludigs
title	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_short	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_full	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_fullStr	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_full_unstemmed	NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
title_sort	nlrc5 shields t lymphocytes from nk-cell-mediated elimination under inflammatory conditions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5daa48a82f9b456488d8d66573ddc116
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NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

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