NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions

NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression.

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Detalles Bibliográficos
Autores principales: Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero, Greta Guarda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/5daa48a82f9b456488d8d66573ddc116
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