A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.

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Auteurs principaux: Chao Quan, Qian Du, Min Li, Ruizhen Wang, Qian Ouyang, Shu Su, Sangsang Zhu, Qiaoli Chen, Yang Sheng, Liang Chen, Hong Wang, David G. Campbell, Carol MacKintosh, Zhongzhou Yang, Kunfu Ouyang, Hong Yu Wang, Shuai Chen
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/5daf127d28454b4bae80efceddb9c9af
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Résumé:Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.

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