A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis

Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.

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Autores principales: Chao Quan, Qian Du, Min Li, Ruizhen Wang, Qian Ouyang, Shu Su, Sangsang Zhu, Qiaoli Chen, Yang Sheng, Liang Chen, Hong Wang, David G. Campbell, Carol MacKintosh, Zhongzhou Yang, Kunfu Ouyang, Hong Yu Wang, Shuai Chen
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5daf127d28454b4bae80efceddb9c9af
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spelling oai:doaj.org-article:5daf127d28454b4bae80efceddb9c9af2021-12-02T17:32:11ZA PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis10.1038/s41467-020-16116-92041-1723https://doaj.org/article/5daf127d28454b4bae80efceddb9c9af2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16116-9https://doaj.org/toc/2041-1723Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.Chao QuanQian DuMin LiRuizhen WangQian OuyangShu SuSangsang ZhuQiaoli ChenYang ShengLiang ChenHong WangDavid G. CampbellCarol MacKintoshZhongzhou YangKunfu OuyangHong Yu WangShuai ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chao Quan
Qian Du
Min Li
Ruizhen Wang
Qian Ouyang
Shu Su
Sangsang Zhu
Qiaoli Chen
Yang Sheng
Liang Chen
Hong Wang
David G. Campbell
Carol MacKintosh
Zhongzhou Yang
Kunfu Ouyang
Hong Yu Wang
Shuai Chen
A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
description Molecular mechanisms linking myocardial insulin resistance to diabetic cardiomyopathy are incompletely understood. Here the authors show that myocardial insulin resistance impairs a PKB-SPEG-SERCA2a signaling axis, which contributes to the development of diabetic cardiomyopathy.
format article
author Chao Quan
Qian Du
Min Li
Ruizhen Wang
Qian Ouyang
Shu Su
Sangsang Zhu
Qiaoli Chen
Yang Sheng
Liang Chen
Hong Wang
David G. Campbell
Carol MacKintosh
Zhongzhou Yang
Kunfu Ouyang
Hong Yu Wang
Shuai Chen
author_facet Chao Quan
Qian Du
Min Li
Ruizhen Wang
Qian Ouyang
Shu Su
Sangsang Zhu
Qiaoli Chen
Yang Sheng
Liang Chen
Hong Wang
David G. Campbell
Carol MacKintosh
Zhongzhou Yang
Kunfu Ouyang
Hong Yu Wang
Shuai Chen
author_sort Chao Quan
title A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
title_short A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
title_full A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
title_fullStr A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
title_full_unstemmed A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
title_sort pkb-speg signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5daf127d28454b4bae80efceddb9c9af
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