Common functional brain networks between attention deficit and disruptive behaviors in youth

Attention deficits (AD) and disruptive behavior (DB) are highly comorbid youth externalizing behaviors. This study aimed to study reliable functional brain networks shared by AD and DB in youth aged from 8 to 21 years from the Philadelphia Neurodevelopmental Cohort (PNC). The PNC study assessed AD a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ting Yat Wong, Han Zhang, Tonya White, Liyuan Xu, Anqi Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Resting-state fMRI Functional connectivity Activation likelihood estimation ADHD DBD Externalizing behavior Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/5db6868087ef4ae8994aa3e951f7c8c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5db6868087ef4ae8994aa3e951f7c8c6
record_format	dspace
spelling	oai:doaj.org-article:5db6868087ef4ae8994aa3e951f7c8c62021-12-04T04:33:16ZCommon functional brain networks between attention deficit and disruptive behaviors in youth1095-957210.1016/j.neuroimage.2021.118732https://doaj.org/article/5db6868087ef4ae8994aa3e951f7c8c62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1053811921010041https://doaj.org/toc/1095-9572Attention deficits (AD) and disruptive behavior (DB) are highly comorbid youth externalizing behaviors. This study aimed to study reliable functional brain networks shared by AD and DB in youth aged from 8 to 21 years from the Philadelphia Neurodevelopmental Cohort (PNC). The PNC study assessed AD and DB behaviors via Kiddie-Schedule for Affective Disorders and Schizophrenia (K-SADS). This study employed sparse canonical correlation analysis (SCCA) to examine the correlation of AD and DB behaviors with resting-state functional connectivity maps of the brain regions identified via activation likelihood estimation (ALE) meta-analyses on attention deficit/hyperactivity disorder (ADHD) and DB disorder (DBD). Our meta-analyses identified that the middle cingulate cortex, pre-supplementary motor area (pre-SMA), and striatum had a great consensus in existing ADHD studies and the amygdala and inferior parietal lobule were consistently found in existing DBD studies. Our SCCA analysis revealed that the AD and DB behavioral items relevant to inattention and delinquency were correlated with the functional connectivity of the pre-SMA with the ventral attentional and frontoparietal networks (FPN), and the striatum with the default mode (DMN) and dorsal attentional networks. The AD and DB behavioral items relevant to inattention and irritability were associated with the functional connectivity between the amygdala and the DMN and FPN. Our findings suggest that the functional organization of the ADHD- and DBD-related brain regions provides insights on the shared neural basis in AD and DB.Ting Yat WongHan ZhangTonya WhiteLiyuan XuAnqi QiuElsevierarticleResting-state fMRIFunctional connectivityActivation likelihood estimationADHDDBDExternalizing behaviorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118732- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Resting-state fMRI Functional connectivity Activation likelihood estimation ADHD DBD Externalizing behavior Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Resting-state fMRI Functional connectivity Activation likelihood estimation ADHD DBD Externalizing behavior Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ting Yat Wong Han Zhang Tonya White Liyuan Xu Anqi Qiu Common functional brain networks between attention deficit and disruptive behaviors in youth
description	Attention deficits (AD) and disruptive behavior (DB) are highly comorbid youth externalizing behaviors. This study aimed to study reliable functional brain networks shared by AD and DB in youth aged from 8 to 21 years from the Philadelphia Neurodevelopmental Cohort (PNC). The PNC study assessed AD and DB behaviors via Kiddie-Schedule for Affective Disorders and Schizophrenia (K-SADS). This study employed sparse canonical correlation analysis (SCCA) to examine the correlation of AD and DB behaviors with resting-state functional connectivity maps of the brain regions identified via activation likelihood estimation (ALE) meta-analyses on attention deficit/hyperactivity disorder (ADHD) and DB disorder (DBD). Our meta-analyses identified that the middle cingulate cortex, pre-supplementary motor area (pre-SMA), and striatum had a great consensus in existing ADHD studies and the amygdala and inferior parietal lobule were consistently found in existing DBD studies. Our SCCA analysis revealed that the AD and DB behavioral items relevant to inattention and delinquency were correlated with the functional connectivity of the pre-SMA with the ventral attentional and frontoparietal networks (FPN), and the striatum with the default mode (DMN) and dorsal attentional networks. The AD and DB behavioral items relevant to inattention and irritability were associated with the functional connectivity between the amygdala and the DMN and FPN. Our findings suggest that the functional organization of the ADHD- and DBD-related brain regions provides insights on the shared neural basis in AD and DB.
format	article
author	Ting Yat Wong Han Zhang Tonya White Liyuan Xu Anqi Qiu
author_facet	Ting Yat Wong Han Zhang Tonya White Liyuan Xu Anqi Qiu
author_sort	Ting Yat Wong
title	Common functional brain networks between attention deficit and disruptive behaviors in youth
title_short	Common functional brain networks between attention deficit and disruptive behaviors in youth
title_full	Common functional brain networks between attention deficit and disruptive behaviors in youth
title_fullStr	Common functional brain networks between attention deficit and disruptive behaviors in youth
title_full_unstemmed	Common functional brain networks between attention deficit and disruptive behaviors in youth
title_sort	common functional brain networks between attention deficit and disruptive behaviors in youth
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5db6868087ef4ae8994aa3e951f7c8c6
work_keys_str_mv	AT tingyatwong commonfunctionalbrainnetworksbetweenattentiondeficitanddisruptivebehaviorsinyouth AT hanzhang commonfunctionalbrainnetworksbetweenattentiondeficitanddisruptivebehaviorsinyouth AT tonyawhite commonfunctionalbrainnetworksbetweenattentiondeficitanddisruptivebehaviorsinyouth AT liyuanxu commonfunctionalbrainnetworksbetweenattentiondeficitanddisruptivebehaviorsinyouth AT anqiqiu commonfunctionalbrainnetworksbetweenattentiondeficitanddisruptivebehaviorsinyouth
_version_	1718372968596242432

Common functional brain networks between attention deficit and disruptive behaviors in youth

Ejemplares similares