The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Abstract Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. The presence of aggressive pathologic risk factors following patients’ primary surgery may warrant the use of adjuvant radiotherapy. It i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lingyun Yang, Jialing Yuan, Xi Zeng, Mingrong Xi, Hongjing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5dbc686f06a2491e9d153d268e20fbaa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5dbc686f06a2491e9d153d268e20fbaa
record_format	dspace
spelling	oai:doaj.org-article:5dbc686f06a2491e9d153d268e20fbaa2021-12-02T17:52:24ZThe outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China10.1038/s41598-020-66661-y2045-2322https://doaj.org/article/5dbc686f06a2491e9d153d268e20fbaa2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66661-yhttps://doaj.org/toc/2045-2322Abstract Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. The presence of aggressive pathologic risk factors following patients’ primary surgery may warrant the use of adjuvant radiotherapy. It is important to weigh up the risks and benefits of using adjuvant radiotherapy for each young patient so as to maximize their prognosis while minimizing the treatment-related morbidity. Methods: A retrospective study was performed. It consisted of 97 patients under 35 years old who were diagnosed with cervical squamous cell carcinoma and underwent treatment at West China Second University Hospital between December 2009 and January 2014. Five-year follow-up, prognostic risks, long-term radiation toxicity, female sexual function, and quality of life were investigated. Results: Adjuvant radiotherapy did improve the prognosis of young patients with lymph node metastases. However, there were few significant differences in progress-free survival and overall survival for the young patients without lymph node metastases following adjuvant radiotherapy. Besides, young patients who took radiotherapy exhibited greater intestinal dysfunction, more severe lower extremities edema, greater sexual dysfunction, and worse long-term quality of life. Conclusion: Young patients with early-stage cervical squamous cell carcinoma without lymph node metastases who have undergone the primary surgery should be counseled in detail before the decision to use adjuvant radiotherapy can be made. The counseling should emphasize not only the benefit that local recurrence rates can be reduced, but also the risks that treatment-related side effects could increase and lower QoL could occur.Lingyun YangJialing YuanXi ZengMingrong XiHongjing WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingyun Yang Jialing Yuan Xi Zeng Mingrong Xi Hongjing Wang The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
description	Abstract Background: The incidence of cervical cancer in young women is rising, and squamous cell carcinoma makes up a great percentage of the histological types. The presence of aggressive pathologic risk factors following patients’ primary surgery may warrant the use of adjuvant radiotherapy. It is important to weigh up the risks and benefits of using adjuvant radiotherapy for each young patient so as to maximize their prognosis while minimizing the treatment-related morbidity. Methods: A retrospective study was performed. It consisted of 97 patients under 35 years old who were diagnosed with cervical squamous cell carcinoma and underwent treatment at West China Second University Hospital between December 2009 and January 2014. Five-year follow-up, prognostic risks, long-term radiation toxicity, female sexual function, and quality of life were investigated. Results: Adjuvant radiotherapy did improve the prognosis of young patients with lymph node metastases. However, there were few significant differences in progress-free survival and overall survival for the young patients without lymph node metastases following adjuvant radiotherapy. Besides, young patients who took radiotherapy exhibited greater intestinal dysfunction, more severe lower extremities edema, greater sexual dysfunction, and worse long-term quality of life. Conclusion: Young patients with early-stage cervical squamous cell carcinoma without lymph node metastases who have undergone the primary surgery should be counseled in detail before the decision to use adjuvant radiotherapy can be made. The counseling should emphasize not only the benefit that local recurrence rates can be reduced, but also the risks that treatment-related side effects could increase and lower QoL could occur.
format	article
author	Lingyun Yang Jialing Yuan Xi Zeng Mingrong Xi Hongjing Wang
author_facet	Lingyun Yang Jialing Yuan Xi Zeng Mingrong Xi Hongjing Wang
author_sort	Lingyun Yang
title	The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
title_short	The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
title_full	The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
title_fullStr	The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
title_full_unstemmed	The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China
title_sort	outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early figo stage cervical squamous cell cancer in southwestern china
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5dbc686f06a2491e9d153d268e20fbaa
work_keys_str_mv	AT lingyunyang theoutcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT jialingyuan theoutcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT xizeng theoutcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT mingrongxi theoutcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT hongjingwang theoutcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT lingyunyang outcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT jialingyuan outcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT xizeng outcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT mingrongxi outcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina AT hongjingwang outcomesandqualityoflifeofyoungpatientsundergoingadjuvantradiotherapyversusnonradiotherapyfollowingsurgerytreatingearlyfigostagecervicalsquamouscellcancerinsouthwesternchina
_version_	1718379228203843584

The outcomes and quality of life of young patients undergoing adjuvant radiotherapy versus non-radiotherapy following surgery treating early FIGO stage cervical squamous cell cancer in southwestern China

Ejemplares similares