Nearest-neighbor amino acids of specificity-determining residues influence the activity of engineered Cre-type recombinases
Abstract The tyrosine-type site-specific DNA recombinase Cre recombines its target site, loxP, with high activity and specificity without cross-recombining the target sites of highly related recombinases. Understanding how Cre achieves this precision is key to be able to rationally engineer site-spe...
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2020
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| Accès en ligne: | https://doaj.org/article/5dbe91c778ae4be9a00457b7e08a610c |
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