Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in <italic toggle="yes">Leishmania donovani</italic>

Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in <italic toggle="yes">Leishmania donovani</italic>

ABSTRACT The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is essential for...

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Autores principales: Eugenia Bifeld, Stephan Lorenzen, Katharina Bartsch, Juan-José Vasquez, T. Nicolai Siegel, Joachim Clos
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
Materias:
HSP90
Leishmania donovani
radicicol
ribosome profiling
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/5dbeae5ae8294a028155e3a33ec51390
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