The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review

Diclofenac (DCF) is a common non-steroidal anti-inflammatory drug (NSAID) that is widely used to control pain and inflammation. There has been much debate about detrimental effects of micro-pollutant such as DCF in non-target organisms. Therefore, the present systematic review (SR) evaluates the pos...

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Autores principales:	Seyyed Abbas Mirzaee, Zahra Noorimotlagh, Mehdi Ahmadi, Fakher Rahim, Susana Silva Martinez, Abdullah Nourmohammadi, Neamat Jaafarzadeh
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diclofenac DNA damage Oxidative stress Ecotoxicological consequences Non-target organisms Aquatic environment Ecology QH540-549.5
Acceso en línea:	https://doaj.org/article/5dbec4121a9243689ecd2b68d7bdbc92
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spelling	oai:doaj.org-article:5dbec4121a9243689ecd2b68d7bdbc922021-12-01T04:59:59ZThe possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review1470-160X10.1016/j.ecolind.2021.108172https://doaj.org/article/5dbec4121a9243689ecd2b68d7bdbc922021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1470160X21008372https://doaj.org/toc/1470-160XDiclofenac (DCF) is a common non-steroidal anti-inflammatory drug (NSAID) that is widely used to control pain and inflammation. There has been much debate about detrimental effects of micro-pollutant such as DCF in non-target organisms. Therefore, the present systematic review (SR) evaluates the possible oxidative stress (OS) and DNA damage induced in DCF-exposed non-target organisms in aquatic environment. A systematic search was conducted in five international literature databases from 1970 to 2021. A comprehensive literature search led to the identification of 14,862 hits, 68 of which met our inclusion criteria. These studies encompassed a wide range of biological endpoints, including OS, DNA damage, cyto-genotoxicity, apoptosis, and estrogenicity potential in non-target organisms. The time, route and types of exposure to DCF was evaluated. There is a strong relationship between DCF exposure and OS, cyto-genotoxicity and DNA damage. Furthermore, there is limited evidence for estrogenic potential of DCF. According to the results of the studies considered in this work, it can be concluded that there is definitive evidence of DCF-induced OS, cyto-genotoxicity and DNA damage on the various types of non-target organisms due to the chronic exposure to DCF. The biomarkers were used to assess adverse consequences and could be used as an early warning signal for environmental monitoring of the presence of pharmaceuticals in aquatic environments. Due to the definitive evidence provided for adverse effects of DCF and multimodel mechanisms of action, it is essential to take a degree of caution to use the DCF and develop the advanced treatment technologies to prevent the release of this type of contaminant to aquatic environments.Seyyed Abbas MirzaeeZahra NoorimotlaghMehdi AhmadiFakher RahimSusana Silva MartinezAbdullah NourmohammadiNeamat JaafarzadehElsevierarticleDiclofenacDNA damageOxidative stressEcotoxicological consequencesNon-target organismsAquatic environmentEcologyQH540-549.5ENEcological Indicators, Vol 131, Iss , Pp 108172- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diclofenac DNA damage Oxidative stress Ecotoxicological consequences Non-target organisms Aquatic environment Ecology QH540-549.5
spellingShingle	Diclofenac DNA damage Oxidative stress Ecotoxicological consequences Non-target organisms Aquatic environment Ecology QH540-549.5 Seyyed Abbas Mirzaee Zahra Noorimotlagh Mehdi Ahmadi Fakher Rahim Susana Silva Martinez Abdullah Nourmohammadi Neamat Jaafarzadeh The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
description	Diclofenac (DCF) is a common non-steroidal anti-inflammatory drug (NSAID) that is widely used to control pain and inflammation. There has been much debate about detrimental effects of micro-pollutant such as DCF in non-target organisms. Therefore, the present systematic review (SR) evaluates the possible oxidative stress (OS) and DNA damage induced in DCF-exposed non-target organisms in aquatic environment. A systematic search was conducted in five international literature databases from 1970 to 2021. A comprehensive literature search led to the identification of 14,862 hits, 68 of which met our inclusion criteria. These studies encompassed a wide range of biological endpoints, including OS, DNA damage, cyto-genotoxicity, apoptosis, and estrogenicity potential in non-target organisms. The time, route and types of exposure to DCF was evaluated. There is a strong relationship between DCF exposure and OS, cyto-genotoxicity and DNA damage. Furthermore, there is limited evidence for estrogenic potential of DCF. According to the results of the studies considered in this work, it can be concluded that there is definitive evidence of DCF-induced OS, cyto-genotoxicity and DNA damage on the various types of non-target organisms due to the chronic exposure to DCF. The biomarkers were used to assess adverse consequences and could be used as an early warning signal for environmental monitoring of the presence of pharmaceuticals in aquatic environments. Due to the definitive evidence provided for adverse effects of DCF and multimodel mechanisms of action, it is essential to take a degree of caution to use the DCF and develop the advanced treatment technologies to prevent the release of this type of contaminant to aquatic environments.
format	article
author	Seyyed Abbas Mirzaee Zahra Noorimotlagh Mehdi Ahmadi Fakher Rahim Susana Silva Martinez Abdullah Nourmohammadi Neamat Jaafarzadeh
author_facet	Seyyed Abbas Mirzaee Zahra Noorimotlagh Mehdi Ahmadi Fakher Rahim Susana Silva Martinez Abdullah Nourmohammadi Neamat Jaafarzadeh
author_sort	Seyyed Abbas Mirzaee
title	The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
title_short	The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
title_full	The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
title_fullStr	The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
title_full_unstemmed	The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review
title_sort	possible oxidative stress and dna damage induced in diclofenac-exposed non-target organisms in the aquatic environment: a systematic review
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5dbec4121a9243689ecd2b68d7bdbc92
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The possible oxidative stress and DNA damage induced in Diclofenac-exposed Non-target organisms in the aquatic environment: A systematic review

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