Adipose Tissue Formation Utilizing Fat Flap Distraction Technique

Abstract Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of a distraction technique on adipose tissue formation and maintenance. Based on the...

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Autores principales:	Myung Chul Lee, Won Jai Lee, Byung Il Lee, Kee Yang Chung, Jae Woo Kim, Eun Hye Kang, Yong Oock Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5dc2f7f623f041c2ab1dbe75737c1332
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spelling	oai:doaj.org-article:5dc2f7f623f041c2ab1dbe75737c13322021-12-02T12:31:51ZAdipose Tissue Formation Utilizing Fat Flap Distraction Technique10.1038/s41598-017-05547-y2045-2322https://doaj.org/article/5dc2f7f623f041c2ab1dbe75737c13322017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05547-yhttps://doaj.org/toc/2045-2322Abstract Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of a distraction technique on adipose tissue formation and maintenance. Based on the hypothesis that fat flaps gradually receding from each other can develop an adipose tissue construct, perforated polycarbonate syringe-shaped chambers were implanted in a rabbit model. Latency (1 week) and distraction (3 weeks) periods were followed by a consolidation period in the experimental groups (4, 8, and 12 weeks). In the distraction group, the volume of fat pad gradually increased up to 16 weeks. A transition zone was observed at 8 weeks, indicating the initiation of tissue generation. Histomorphologic analysis showed adipose and collagen connective tissue at 8 weeks. At 16 weeks, the relative composition was altered significantly. Adipose components occupied most of the tissue, and connective tissue was reduced. Blood vessels with endothelial lining were noted adjacent to adipocyte clusters, as well as in inter-adipocyte areas. The vessels had increased in number and were evenly distributed by 16 weeks. Our distraction technique produced more balanced adipose tissue generation than a non-distraction method, with co-development of adipose and vascular tissues.Myung Chul LeeWon Jai LeeByung Il LeeKee Yang ChungJae Woo KimEun Hye KangYong Oock KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myung Chul Lee Won Jai Lee Byung Il Lee Kee Yang Chung Jae Woo Kim Eun Hye Kang Yong Oock Kim Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
description	Abstract Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of a distraction technique on adipose tissue formation and maintenance. Based on the hypothesis that fat flaps gradually receding from each other can develop an adipose tissue construct, perforated polycarbonate syringe-shaped chambers were implanted in a rabbit model. Latency (1 week) and distraction (3 weeks) periods were followed by a consolidation period in the experimental groups (4, 8, and 12 weeks). In the distraction group, the volume of fat pad gradually increased up to 16 weeks. A transition zone was observed at 8 weeks, indicating the initiation of tissue generation. Histomorphologic analysis showed adipose and collagen connective tissue at 8 weeks. At 16 weeks, the relative composition was altered significantly. Adipose components occupied most of the tissue, and connective tissue was reduced. Blood vessels with endothelial lining were noted adjacent to adipocyte clusters, as well as in inter-adipocyte areas. The vessels had increased in number and were evenly distributed by 16 weeks. Our distraction technique produced more balanced adipose tissue generation than a non-distraction method, with co-development of adipose and vascular tissues.
format	article
author	Myung Chul Lee Won Jai Lee Byung Il Lee Kee Yang Chung Jae Woo Kim Eun Hye Kang Yong Oock Kim
author_facet	Myung Chul Lee Won Jai Lee Byung Il Lee Kee Yang Chung Jae Woo Kim Eun Hye Kang Yong Oock Kim
author_sort	Myung Chul Lee
title	Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
title_short	Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
title_full	Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
title_fullStr	Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
title_full_unstemmed	Adipose Tissue Formation Utilizing Fat Flap Distraction Technique
title_sort	adipose tissue formation utilizing fat flap distraction technique
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5dc2f7f623f041c2ab1dbe75737c1332
work_keys_str_mv	AT myungchullee adiposetissueformationutilizingfatflapdistractiontechnique AT wonjailee adiposetissueformationutilizingfatflapdistractiontechnique AT byungillee adiposetissueformationutilizingfatflapdistractiontechnique AT keeyangchung adiposetissueformationutilizingfatflapdistractiontechnique AT jaewookim adiposetissueformationutilizingfatflapdistractiontechnique AT eunhyekang adiposetissueformationutilizingfatflapdistractiontechnique AT yongoockkim adiposetissueformationutilizingfatflapdistractiontechnique
_version_	1718394216112979968

Adipose Tissue Formation Utilizing Fat Flap Distraction Technique

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