Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices

<h4>Objective</h4> Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory resp...

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Autores principales:	Haitham Abu Khadija, Gera Gandelman, Omar Ayyad, Mustafa Jaber, Lion Poles, Michael Jonas, Offir Paz, Firas Abu Sbaih, Gal Sella, Sara Shimoni, Jacob George, Alex Blatt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5dc46a56fbbb49aaa75ae3b6d635a6ca
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spelling	oai:doaj.org-article:5dc46a56fbbb49aaa75ae3b6d635a6ca2021-11-04T06:19:43ZDifferential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices1932-6203https://doaj.org/article/5dc46a56fbbb49aaa75ae3b6d635a6ca2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547641/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4> Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory response remains uncertain. <h4>Materials and methods</h4> Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) and subpopulation dynamics as well the neutrophil to lymphocyte ratio (NLR) were evaluated. <h4>Results</h4> Three-hundred seventy consecutive patients (mean age 81.75 ± 6.8 years, 199 women’s) were enrolled. In the entire population, significant kinetic changes in the WBC response (p <0.0001) between admission and first 24 hours post procedure, with a significant increase in total WBC (7.46 ± 2.26 to 10.08 ± 3.55) and absolute neutrophil count (4.97 ± 2.06 to 8.19 ± 3.43), NL ratio (3.72 ± 2.8 to 9.76 ± 7.29), and a meaningful decrease in absolute lymphocytes count (1.67 ± 1.1 to 1.1 ± 0.76). When compared between the types of valves, SEVs were associated with a more pronounced inflammatory response than BEVs, with total WBC (10.44 ± 3.86 vs. 9.45 ± 3.19) neutrophils (8.56 ± 3.75 vs. 7.55 ± 3.06) with p 0.016 and 0.012 respectively. <h4>Conclusion</h4> This is the first description of a differential inflammatory response between the two leading delivery systems. SEV appears to trigger a more robust inflammatory response as compared to BEV. Clinical studies are warranted to assess the long term effect of our findings.Haitham Abu KhadijaGera GandelmanOmar AyyadMustafa JaberLion PolesMichael JonasOffir PazFiras Abu SbaihGal SellaSara ShimoniJacob GeorgeAlex BlattPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Haitham Abu Khadija Gera Gandelman Omar Ayyad Mustafa Jaber Lion Poles Michael Jonas Offir Paz Firas Abu Sbaih Gal Sella Sara Shimoni Jacob George Alex Blatt Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
description	<h4>Objective</h4> Transcatheter aortic valve implantation (TAVI) provokes early injury response, represented in part by dynamic changes in the inflammatory markers. The association of self-expanding valves (SEVs) and balloon-expandable valves (BEVs) with the consequent inflammatory response remains uncertain. <h4>Materials and methods</h4> Patients with severe symptomatic aortic stenosis who underwent transfemoral TAVI: SEVs or BEVs, from January 2010 to December 2019 were enrolled. Whole white blood cells (WBC) and subpopulation dynamics as well the neutrophil to lymphocyte ratio (NLR) were evaluated. <h4>Results</h4> Three-hundred seventy consecutive patients (mean age 81.75 ± 6.8 years, 199 women’s) were enrolled. In the entire population, significant kinetic changes in the WBC response (p <0.0001) between admission and first 24 hours post procedure, with a significant increase in total WBC (7.46 ± 2.26 to 10.08 ± 3.55) and absolute neutrophil count (4.97 ± 2.06 to 8.19 ± 3.43), NL ratio (3.72 ± 2.8 to 9.76 ± 7.29), and a meaningful decrease in absolute lymphocytes count (1.67 ± 1.1 to 1.1 ± 0.76). When compared between the types of valves, SEVs were associated with a more pronounced inflammatory response than BEVs, with total WBC (10.44 ± 3.86 vs. 9.45 ± 3.19) neutrophils (8.56 ± 3.75 vs. 7.55 ± 3.06) with p 0.016 and 0.012 respectively. <h4>Conclusion</h4> This is the first description of a differential inflammatory response between the two leading delivery systems. SEV appears to trigger a more robust inflammatory response as compared to BEV. Clinical studies are warranted to assess the long term effect of our findings.
format	article
author	Haitham Abu Khadija Gera Gandelman Omar Ayyad Mustafa Jaber Lion Poles Michael Jonas Offir Paz Firas Abu Sbaih Gal Sella Sara Shimoni Jacob George Alex Blatt
author_facet	Haitham Abu Khadija Gera Gandelman Omar Ayyad Mustafa Jaber Lion Poles Michael Jonas Offir Paz Firas Abu Sbaih Gal Sella Sara Shimoni Jacob George Alex Blatt
author_sort	Haitham Abu Khadija
title	Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
title_short	Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
title_full	Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
title_fullStr	Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
title_full_unstemmed	Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices
title_sort	differential systemic inflammatory responses after tavi: the role of self versus balloon expandable devices
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5dc46a56fbbb49aaa75ae3b6d635a6ca
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Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices

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