Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD

BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivi...

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Autores principales:	Shuiqing Lai, Jiarong Li, Zixiao Wang, Wei Wang, Haixia Guan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	thyroid function sensitivity to thyroid hormone indices thyroid feedback quantile-based index dyslipidemia non‐alcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/5dc6c16244ac4a599c9bd8c830af5893
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spelling	oai:doaj.org-article:5dc6c16244ac4a599c9bd8c830af58932021-11-05T14:51:58ZSensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD1664-239210.3389/fendo.2021.766419https://doaj.org/article/5dc6c16244ac4a599c9bd8c830af58932021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.766419/fullhttps://doaj.org/toc/1664-2392BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQIFT4) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQIFT3 index. NAFLD was defined using abdominal ultrasound.ResultsStudy results showed that FT3/FT4 and TFQIFT3 were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P<0.05). In contrast, TFQIFT4 was positively correlated with HDL-C level (P < 0.05). After adjustment for multiple confounders, FT3, FT3/FT4, and TFQIFT3 were positively associated with the risks of dyslipidemia and NAFLD (P < 0.05). TFQIFT3 and FT3/FT4 performed better than TFQIFT4 on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQIFT4 with the risks of dyslipidemia and NAFLD.ConclusionTFQIFT3 and FT3/FT4 can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQIFT4 has insufficient evidence in predicting dyslipidemia and NAFLD.Shuiqing LaiJiarong LiJiarong LiZixiao WangWei WangHaixia GuanFrontiers Media S.A.articlethyroid functionsensitivity to thyroid hormone indicesthyroid feedback quantile-based indexdyslipidemianon‐alcoholic fatty liver diseaseDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thyroid function sensitivity to thyroid hormone indices thyroid feedback quantile-based index dyslipidemia non‐alcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	thyroid function sensitivity to thyroid hormone indices thyroid feedback quantile-based index dyslipidemia non‐alcoholic fatty liver disease Diseases of the endocrine glands. Clinical endocrinology RC648-665 Shuiqing Lai Jiarong Li Jiarong Li Zixiao Wang Wei Wang Haixia Guan Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
description	BackgroundPrevious studies on the association between thyroid function and non‐alcoholic fatty liver disease (NAFLD) have contradicted. Acquired resistance to thyroid hormone theory might provide a reasonable explanation for these contradictions. We aimed to analyze the association between sensitivity to thyroid hormone indices with NAFLD.MethodsA total of 4,610 individuals from the health medical center of the First Hospital of China Medical University were included in this study. The previously used thyroid feedback quantile-based index (TFQIFT4) was calculated. Also, we substituted free triiodothyronine (FT3) into the TFQI formulas to get the TFQIFT3 index. NAFLD was defined using abdominal ultrasound.ResultsStudy results showed that FT3/FT4 and TFQIFT3 were positively correlated with the triglyceride (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels (P<0.05) and negatively correlated with high-density lipoprotein cholesterol (HDL-C) level (P<0.05). In contrast, TFQIFT4 was positively correlated with HDL-C level (P < 0.05). After adjustment for multiple confounders, FT3, FT3/FT4, and TFQIFT3 were positively associated with the risks of dyslipidemia and NAFLD (P < 0.05). TFQIFT3 and FT3/FT4 performed better than TFQIFT4 on ROC analyses for NAFLD prediction, although the diagnostic sensitivity and specificity at the optimal cut-points were low. However, no association was observed between TFQIFT4 with the risks of dyslipidemia and NAFLD.ConclusionTFQIFT3 and FT3/FT4 can be used as new indicators for predicting dyslipidemia and NAFLD, although with low sensitivity and specificity at the optimal cut-points, while TFQIFT4 has insufficient evidence in predicting dyslipidemia and NAFLD.
format	article
author	Shuiqing Lai Jiarong Li Jiarong Li Zixiao Wang Wei Wang Haixia Guan
author_facet	Shuiqing Lai Jiarong Li Jiarong Li Zixiao Wang Wei Wang Haixia Guan
author_sort	Shuiqing Lai
title	Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
title_short	Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
title_full	Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
title_fullStr	Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
title_full_unstemmed	Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD
title_sort	sensitivity to thyroid hormone indices are closely associated with nafld
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5dc6c16244ac4a599c9bd8c830af5893
work_keys_str_mv	AT shuiqinglai sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld AT jiarongli sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld AT jiarongli sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld AT zixiaowang sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld AT weiwang sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld AT haixiaguan sensitivitytothyroidhormoneindicesarecloselyassociatedwithnafld
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Sensitivity to Thyroid Hormone Indices Are Closely Associated With NAFLD

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