Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S. aureus growth and virulence by inhibiting de novo purine biosynthesis and toxin pr...

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Autores principales:	Denny Chin, Mariya I. Goncheva, Ronald S. Flannagan, Shayna R. Deecker, Veronica Guariglia-Oropeza, Alexander W. Ensminger, David E. Heinrichs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5dc9d989ac09491a87fc0cd58ee70674
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spelling	oai:doaj.org-article:5dc9d989ac09491a87fc0cd58ee706742021-12-02T14:02:51ZCoagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence10.1038/s41467-021-22175-32041-1723https://doaj.org/article/5dc9d989ac09491a87fc0cd58ee706742021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22175-3https://doaj.org/toc/2041-1723Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S. aureus growth and virulence by inhibiting de novo purine biosynthesis and toxin production.Denny ChinMariya I. GonchevaRonald S. FlannaganShayna R. DeeckerVeronica Guariglia-OropezaAlexander W. EnsmingerDavid E. HeinrichsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Denny Chin Mariya I. Goncheva Ronald S. Flannagan Shayna R. Deecker Veronica Guariglia-Oropeza Alexander W. Ensminger David E. Heinrichs Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
description	Coagulase-negative staphylococci and Staphylococcus aureus colonize similar niches in mammals. Here, Chin et al. show that a coagulase-negative staphylococcus secretes 6-thioguanine, a purine analog that suppresses S. aureus growth and virulence by inhibiting de novo purine biosynthesis and toxin production.
format	article
author	Denny Chin Mariya I. Goncheva Ronald S. Flannagan Shayna R. Deecker Veronica Guariglia-Oropeza Alexander W. Ensminger David E. Heinrichs
author_facet	Denny Chin Mariya I. Goncheva Ronald S. Flannagan Shayna R. Deecker Veronica Guariglia-Oropeza Alexander W. Ensminger David E. Heinrichs
author_sort	Denny Chin
title	Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
title_short	Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
title_full	Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
title_fullStr	Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
title_full_unstemmed	Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence
title_sort	coagulase-negative staphylococci release a purine analog that inhibits staphylococcus aureus virulence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5dc9d989ac09491a87fc0cd58ee70674
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Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence

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