Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo

Nowadays, 3D printing technology has been applied in dentistry to fabricate customized implants. However, the biological performance is unsatisfactory. Polydopamine (PDA) has been used to immobilize bioactive agents on implant surfaces to endow them with multiple properties, such as anti-infection a...

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Autores principales:	Hui Wang, Changyong Yuan, Kaili Lin, Rui Zhu, Shilei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	3D printing titanium alloy implants surface modification polydopamine osteogenesis Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/5dcc1d69972f46fca2b400c6b657697b
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spelling	oai:doaj.org-article:5dcc1d69972f46fca2b400c6b657697b2021-12-02T15:41:22ZModifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo2296-418510.3389/fbioe.2021.761911https://doaj.org/article/5dcc1d69972f46fca2b400c6b657697b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.761911/fullhttps://doaj.org/toc/2296-4185Nowadays, 3D printing technology has been applied in dentistry to fabricate customized implants. However, the biological performance is unsatisfactory. Polydopamine (PDA) has been used to immobilize bioactive agents on implant surfaces to endow them with multiple properties, such as anti-infection and pro-osteogenesis, benefiting rapid osseointegration. Herein, we fabricated a PDA coating on a 3D-printed implant surface (3D-PDA) via the in situ polymerization method. Then the 3D-PDA implants’ pro-osteogenesis capacity and the osseointegration performance were evaluated in comparison with the 3D group. The in vitro results revealed that the PDA coating modification increased the hydrophilicity of the implants, promoting the improvement of the adhesion, propagation, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. Additionally, the 3D-PDA implant improved osteointegration performance in vivo. The present study suggested that PDA coating might be a feasible strategy to optimize 3D-printed implant surfaces, making a preliminary research basis for the subsequent work to immobilize bioactive factors on the 3D-printed implant surface.Hui WangChangyong YuanKaili LinRui ZhuShilei ZhangFrontiers Media S.A.article3D printingtitanium alloy implantssurface modificationpolydopamineosteogenesisBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing titanium alloy implants surface modification polydopamine osteogenesis Biotechnology TP248.13-248.65
spellingShingle	3D printing titanium alloy implants surface modification polydopamine osteogenesis Biotechnology TP248.13-248.65 Hui Wang Changyong Yuan Kaili Lin Rui Zhu Shilei Zhang Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
description	Nowadays, 3D printing technology has been applied in dentistry to fabricate customized implants. However, the biological performance is unsatisfactory. Polydopamine (PDA) has been used to immobilize bioactive agents on implant surfaces to endow them with multiple properties, such as anti-infection and pro-osteogenesis, benefiting rapid osseointegration. Herein, we fabricated a PDA coating on a 3D-printed implant surface (3D-PDA) via the in situ polymerization method. Then the 3D-PDA implants’ pro-osteogenesis capacity and the osseointegration performance were evaluated in comparison with the 3D group. The in vitro results revealed that the PDA coating modification increased the hydrophilicity of the implants, promoting the improvement of the adhesion, propagation, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. Additionally, the 3D-PDA implant improved osteointegration performance in vivo. The present study suggested that PDA coating might be a feasible strategy to optimize 3D-printed implant surfaces, making a preliminary research basis for the subsequent work to immobilize bioactive factors on the 3D-printed implant surface.
format	article
author	Hui Wang Changyong Yuan Kaili Lin Rui Zhu Shilei Zhang
author_facet	Hui Wang Changyong Yuan Kaili Lin Rui Zhu Shilei Zhang
author_sort	Hui Wang
title	Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
title_short	Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
title_full	Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
title_fullStr	Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
title_full_unstemmed	Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo
title_sort	modifying a 3d-printed ti6al4v implant with polydopamine coating to improve bmscs growth, osteogenic differentiation, and in situ osseointegration in vivo
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5dcc1d69972f46fca2b400c6b657697b
work_keys_str_mv	AT huiwang modifyinga3dprintedti6al4vimplantwithpolydopaminecoatingtoimprovebmscsgrowthosteogenicdifferentiationandinsituosseointegrationinvivo AT changyongyuan modifyinga3dprintedti6al4vimplantwithpolydopaminecoatingtoimprovebmscsgrowthosteogenicdifferentiationandinsituosseointegrationinvivo AT kaililin modifyinga3dprintedti6al4vimplantwithpolydopaminecoatingtoimprovebmscsgrowthosteogenicdifferentiationandinsituosseointegrationinvivo AT ruizhu modifyinga3dprintedti6al4vimplantwithpolydopaminecoatingtoimprovebmscsgrowthosteogenicdifferentiationandinsituosseointegrationinvivo AT shileizhang modifyinga3dprintedti6al4vimplantwithpolydopaminecoatingtoimprovebmscsgrowthosteogenicdifferentiationandinsituosseointegrationinvivo
_version_	1718385808964059136

Modifying a 3D-Printed Ti6Al4V Implant with Polydopamine Coating to Improve BMSCs Growth, Osteogenic Differentiation, and In Situ Osseointegration In Vivo

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