Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets

Elmas et al. develop an algorithm, OPPTI, to identify overexpressed kinase proteins across 10 cancer types using global mass spectrometry proteomics data from over 1000 cases. They reveal that protein-level aberrations, which are sometimes not observed using genomics, represent cancer vulnerabilitie...

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Autores principales: Abdulkadir Elmas, Serena Tharakan, Suraj Jaladanki, Matthew D. Galsky, Tao Liu, Kuan-lin Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5dd05a2677074ae39b5bc5377823049c
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Sumario:Elmas et al. develop an algorithm, OPPTI, to identify overexpressed kinase proteins across 10 cancer types using global mass spectrometry proteomics data from over 1000 cases. They reveal that protein-level aberrations, which are sometimes not observed using genomics, represent cancer vulnerabilities that may be targeted in precision oncology.