Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors.

In a structure-activity relationship (SAR) study, 3-methoxy-1,4-phenanthrenequinones, calanquinone A (6a), denbinobin (6b), 5-OAc-calanquinone A (7a) and 5-OAc-denbinobin (7b), have significantly promising cytotoxicity against various human cancer cell lines (IC(50) 0.08-1.66 µg/mL). Moreover, we al...

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Auteurs principaux:	Chia-Lin Lee, Ying-Ting Lin, Fang-Rong Chang, Guan-Yu Chen, Anders Backlund, Juan-Chang Yang, Shu-Li Chen, Yang-Chang Wu
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2012
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/5dd210b9d8134dde9b990dd2ef11534c
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