The histone methyltransferase Setd2 is indispensable for V(D)J recombination

The histone methyltransferase Setd2 is indispensable for V(D)J recombination

The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental bloc...

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Main Authors: Zhongzhong Ji, Yaru Sheng, Juju Miao, Xiaoxia Li, Huifang Zhao, Jinming Wang, Chaping Cheng, Xue Wang, Kaiyuan Liu, Kai Zhang, Longmei Xu, Jufang Yao, Lijing Shen, Jian Hou, Wenhao Zhou, Jinqiao Sun, Li Li, Wei-Qiang Gao, Helen He Zhu
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
Q
Online Access:https://doaj.org/article/5dd289baf46d4c539880319ed81680bb
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Summary:The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental blocks in both T and B lineages.

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