The histone methyltransferase Setd2 is indispensable for V(D)J recombination

The histone methyltransferase Setd2 is indispensable for V(D)J recombination

The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental bloc...

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Autores principales: Zhongzhong Ji, Yaru Sheng, Juju Miao, Xiaoxia Li, Huifang Zhao, Jinming Wang, Chaping Cheng, Xue Wang, Kaiyuan Liu, Kai Zhang, Longmei Xu, Jufang Yao, Lijing Shen, Jian Hou, Wenhao Zhou, Jinqiao Sun, Li Li, Wei-Qiang Gao, Helen He Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5dd289baf46d4c539880319ed81680bb
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spelling oai:doaj.org-article:5dd289baf46d4c539880319ed81680bb2021-12-02T15:35:14ZThe histone methyltransferase Setd2 is indispensable for V(D)J recombination10.1038/s41467-019-11282-x2041-1723https://doaj.org/article/5dd289baf46d4c539880319ed81680bb2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11282-xhttps://doaj.org/toc/2041-1723The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental blocks in both T and B lineages.Zhongzhong JiYaru ShengJuju MiaoXiaoxia LiHuifang ZhaoJinming WangChaping ChengXue WangKaiyuan LiuKai ZhangLongmei XuJufang YaoLijing ShenJian HouWenhao ZhouJinqiao SunLi LiWei-Qiang GaoHelen He ZhuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhongzhong Ji
Yaru Sheng
Juju Miao
Xiaoxia Li
Huifang Zhao
Jinming Wang
Chaping Cheng
Xue Wang
Kaiyuan Liu
Kai Zhang
Longmei Xu
Jufang Yao
Lijing Shen
Jian Hou
Wenhao Zhou
Jinqiao Sun
Li Li
Wei-Qiang Gao
Helen He Zhu
The histone methyltransferase Setd2 is indispensable for V(D)J recombination
description The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental blocks in both T and B lineages.
format article
author Zhongzhong Ji
Yaru Sheng
Juju Miao
Xiaoxia Li
Huifang Zhao
Jinming Wang
Chaping Cheng
Xue Wang
Kaiyuan Liu
Kai Zhang
Longmei Xu
Jufang Yao
Lijing Shen
Jian Hou
Wenhao Zhou
Jinqiao Sun
Li Li
Wei-Qiang Gao
Helen He Zhu
author_facet Zhongzhong Ji
Yaru Sheng
Juju Miao
Xiaoxia Li
Huifang Zhao
Jinming Wang
Chaping Cheng
Xue Wang
Kaiyuan Liu
Kai Zhang
Longmei Xu
Jufang Yao
Lijing Shen
Jian Hou
Wenhao Zhou
Jinqiao Sun
Li Li
Wei-Qiang Gao
Helen He Zhu
author_sort Zhongzhong Ji
title The histone methyltransferase Setd2 is indispensable for V(D)J recombination
title_short The histone methyltransferase Setd2 is indispensable for V(D)J recombination
title_full The histone methyltransferase Setd2 is indispensable for V(D)J recombination
title_fullStr The histone methyltransferase Setd2 is indispensable for V(D)J recombination
title_full_unstemmed The histone methyltransferase Setd2 is indispensable for V(D)J recombination
title_sort histone methyltransferase setd2 is indispensable for v(d)j recombination
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/5dd289baf46d4c539880319ed81680bb
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