The histone methyltransferase Setd2 is indispensable for V(D)J recombination
The repertoire of adaptive immune receptor is generated by V(D)J recombination, somatic rearrangements of V, D and J gene segments, in the respective loci. Here the authors show that the deficiency of Setd2, a histone methyl transfer, impairs V(D)J recombination and induces severe developmental bloc...
Guardado en:
Autores principales: | Zhongzhong Ji, Yaru Sheng, Juju Miao, Xiaoxia Li, Huifang Zhao, Jinming Wang, Chaping Cheng, Xue Wang, Kaiyuan Liu, Kai Zhang, Longmei Xu, Jufang Yao, Lijing Shen, Jian Hou, Wenhao Zhou, Jinqiao Sun, Li Li, Wei-Qiang Gao, Helen He Zhu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/5dd289baf46d4c539880319ed81680bb |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Structural basis for the target specificity of actin histidine methyltransferase SETD3
por: Shaobo Dai, et al.
Publicado: (2019) -
Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing
por: Saikat Bhattacharya, et al.
Publicado: (2021) -
Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters
por: Hyung Suk Oh, et al.
Publicado: (2015) -
The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
por: Saikat Bhattacharya, et al.
Publicado: (2021) -
Structural and functional profiling of the human histone methyltransferase SMYD3.
por: Kenneth W Foreman, et al.
Publicado: (2011)