On Placental Toxicology Studies and Cerium Dioxide Nanoparticles

The human placenta is a transient organ essential for pregnancy maintenance, fetal development and growth. It has several functions, including that of a selective barrier against pathogens and xenobiotics from maternal blood. However, some pollutants can accumulate in the placenta or pass through wi...

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Autores principales:	Gaëlle Deval, Sonja Boland, Thierry Fournier, Ioana Ferecatu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoparticles nanoceria cerium dioxide human placenta placental barrier toxicology studies Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5dd5078d0c1449f4876f6a96a7098146
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spelling	oai:doaj.org-article:5dd5078d0c1449f4876f6a96a70981462021-11-25T17:54:49ZOn Placental Toxicology Studies and Cerium Dioxide Nanoparticles10.3390/ijms2222122661422-00671661-6596https://doaj.org/article/5dd5078d0c1449f4876f6a96a70981462021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12266https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The human placenta is a transient organ essential for pregnancy maintenance, fetal development and growth. It has several functions, including that of a selective barrier against pathogens and xenobiotics from maternal blood. However, some pollutants can accumulate in the placenta or pass through with possible repercussions on pregnancy outcomes. Cerium dioxide nanoparticles (CeO<sub>2</sub> NPs), also termed nanoceria, are an emerging pollutant whose impact on pregnancy is starting to be defined. CeO<sub>2</sub> NPs are already used in different fields for industrial and commercial applications and have even been proposed for some biomedical applications. Since 2010, nanoceria have been subject to priority monitoring by the Organization for Economic Co-operation and Development in order to assess their toxicity. This review aims to summarize the current methods and models used for toxicology studies on the placental barrier, from the basic ones to the very latest, as well as to overview the most recent knowledge of the impact of CeO<sub>2</sub> NPs on human health, and more specifically during the sensitive window of pregnancy. Further research is needed to highlight the relationship between environmental exposure to CeO<sub>2</sub> and placental dysfunction with its implications for pregnancy outcome.Gaëlle DevalSonja BolandThierry FournierIoana FerecatuMDPI AGarticlenanoparticlesnanoceriacerium dioxidehuman placentaplacental barriertoxicology studiesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12266, p 12266 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticles nanoceria cerium dioxide human placenta placental barrier toxicology studies Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	nanoparticles nanoceria cerium dioxide human placenta placental barrier toxicology studies Biology (General) QH301-705.5 Chemistry QD1-999 Gaëlle Deval Sonja Boland Thierry Fournier Ioana Ferecatu On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
description	The human placenta is a transient organ essential for pregnancy maintenance, fetal development and growth. It has several functions, including that of a selective barrier against pathogens and xenobiotics from maternal blood. However, some pollutants can accumulate in the placenta or pass through with possible repercussions on pregnancy outcomes. Cerium dioxide nanoparticles (CeO<sub>2</sub> NPs), also termed nanoceria, are an emerging pollutant whose impact on pregnancy is starting to be defined. CeO<sub>2</sub> NPs are already used in different fields for industrial and commercial applications and have even been proposed for some biomedical applications. Since 2010, nanoceria have been subject to priority monitoring by the Organization for Economic Co-operation and Development in order to assess their toxicity. This review aims to summarize the current methods and models used for toxicology studies on the placental barrier, from the basic ones to the very latest, as well as to overview the most recent knowledge of the impact of CeO<sub>2</sub> NPs on human health, and more specifically during the sensitive window of pregnancy. Further research is needed to highlight the relationship between environmental exposure to CeO<sub>2</sub> and placental dysfunction with its implications for pregnancy outcome.
format	article
author	Gaëlle Deval Sonja Boland Thierry Fournier Ioana Ferecatu
author_facet	Gaëlle Deval Sonja Boland Thierry Fournier Ioana Ferecatu
author_sort	Gaëlle Deval
title	On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
title_short	On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
title_full	On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
title_fullStr	On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
title_full_unstemmed	On Placental Toxicology Studies and Cerium Dioxide Nanoparticles
title_sort	on placental toxicology studies and cerium dioxide nanoparticles
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5dd5078d0c1449f4876f6a96a7098146
work_keys_str_mv	AT gaelledeval onplacentaltoxicologystudiesandceriumdioxidenanoparticles AT sonjaboland onplacentaltoxicologystudiesandceriumdioxidenanoparticles AT thierryfournier onplacentaltoxicologystudiesandceriumdioxidenanoparticles AT ioanaferecatu onplacentaltoxicologystudiesandceriumdioxidenanoparticles
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On Placental Toxicology Studies and Cerium Dioxide Nanoparticles

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