Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study

Abstract Responses of different neurons to electric field (EF) are highly variable, which depends on intrinsic properties of cell type. Here we use multi-compartmental biophysical models to investigate how morphologic features affect EF-induced responses in hippocampal CA1 pyramidal neurons. We find...

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Autores principales:	Guo-Sheng Yi, Jiang Wang, Bin Deng, Xi-Le Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5dd76b59da894fc5b4d93d1a2b4a3641
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spelling	oai:doaj.org-article:5dd76b59da894fc5b4d93d1a2b4a36412021-12-02T11:53:07ZMorphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study10.1038/s41598-017-03547-62045-2322https://doaj.org/article/5dd76b59da894fc5b4d93d1a2b4a36412017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03547-6https://doaj.org/toc/2045-2322Abstract Responses of different neurons to electric field (EF) are highly variable, which depends on intrinsic properties of cell type. Here we use multi-compartmental biophysical models to investigate how morphologic features affect EF-induced responses in hippocampal CA1 pyramidal neurons. We find that the basic morphologies of neuronal elements, including diameter, length, bend, branch, and axon terminals, are all correlated with somatic depolarization through altering the current sources or sinks created by applied field. Varying them alters the EF threshold for triggering action potentials (APs), and then determines cell sensitivity to suprathreshold field. Introducing excitatory postsynaptic potential increases cell excitability and reduces morphology-dependent EF firing threshold. It is also shown that applying identical subthreshold EF results in distinct polarizations on cell membrane with different realistic morphologies. These findings shed light on the crucial role of morphologies in determining field-induced neural response from the point of view of biophysical models. The predictions are conducive to better understanding the variability in modulatory effects of EF stimulation at the cellular level, which could also aid the interpretations of how applied fields activate central nervous system neurons and affect relevant circuits.Guo-Sheng YiJiang WangBin DengXi-Le WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guo-Sheng Yi Jiang Wang Bin Deng Xi-Le Wei Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
description	Abstract Responses of different neurons to electric field (EF) are highly variable, which depends on intrinsic properties of cell type. Here we use multi-compartmental biophysical models to investigate how morphologic features affect EF-induced responses in hippocampal CA1 pyramidal neurons. We find that the basic morphologies of neuronal elements, including diameter, length, bend, branch, and axon terminals, are all correlated with somatic depolarization through altering the current sources or sinks created by applied field. Varying them alters the EF threshold for triggering action potentials (APs), and then determines cell sensitivity to suprathreshold field. Introducing excitatory postsynaptic potential increases cell excitability and reduces morphology-dependent EF firing threshold. It is also shown that applying identical subthreshold EF results in distinct polarizations on cell membrane with different realistic morphologies. These findings shed light on the crucial role of morphologies in determining field-induced neural response from the point of view of biophysical models. The predictions are conducive to better understanding the variability in modulatory effects of EF stimulation at the cellular level, which could also aid the interpretations of how applied fields activate central nervous system neurons and affect relevant circuits.
format	article
author	Guo-Sheng Yi Jiang Wang Bin Deng Xi-Le Wei
author_facet	Guo-Sheng Yi Jiang Wang Bin Deng Xi-Le Wei
author_sort	Guo-Sheng Yi
title	Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
title_short	Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
title_full	Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
title_fullStr	Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
title_full_unstemmed	Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
title_sort	morphology controls how hippocampal ca1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5dd76b59da894fc5b4d93d1a2b4a3641
work_keys_str_mv	AT guoshengyi morphologycontrolshowhippocampalca1pyramidalneuronrespondstouniformelectricfieldsabiophysicalmodelingstudy AT jiangwang morphologycontrolshowhippocampalca1pyramidalneuronrespondstouniformelectricfieldsabiophysicalmodelingstudy AT bindeng morphologycontrolshowhippocampalca1pyramidalneuronrespondstouniformelectricfieldsabiophysicalmodelingstudy AT xilewei morphologycontrolshowhippocampalca1pyramidalneuronrespondstouniformelectricfieldsabiophysicalmodelingstudy
_version_	1718394867569131520

Morphology controls how hippocampal CA1 pyramidal neuron responds to uniform electric fields: a biophysical modeling study

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