The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.

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Autores principales:	Xiaoping Xu, Kai Ni, Yafeng He, Jianke Ren, Chongkui Sun, Yie Liu, Mirit I. Aladjem, Sandra Burkett, Richard Finney, Xia Ding, Shyam K. Sharan, Kathrin Muegge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5dd84ce1725948758084a5a36813c4ed
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spelling	oai:doaj.org-article:5dd84ce1725948758084a5a36813c4ed2021-12-02T17:47:33ZThe epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation10.1038/s41467-021-23809-22041-1723https://doaj.org/article/5dd84ce1725948758084a5a36813c4ed2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23809-2https://doaj.org/toc/2041-1723LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.Xiaoping XuKai NiYafeng HeJianke RenChongkui SunYie LiuMirit I. AladjemSandra BurkettRichard FinneyXia DingShyam K. SharanKathrin MueggeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
description	LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.
format	article
author	Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge
author_facet	Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge
author_sort	Xiaoping Xu
title	The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
title_short	The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
title_full	The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
title_fullStr	The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
title_full_unstemmed	The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
title_sort	epigenetic regulator lsh maintains fork protection and genomic stability via macroh2a deposition and rad51 filament formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5dd84ce1725948758084a5a36813c4ed
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The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation

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