Exodontia associated bacteremia in horses characterized by next generation sequencing

Abstract Bacteremia resulting from dental surgery is increasingly recognized as a health risk, especially in older and immunocompromised patients. Dentistry-associated bacteremia can lead to remote infections, as exemplified by valvular endocarditis. Emerging evidence points to a novel role played b...

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Autores principales:	Kile S. Townsend, Philip J. Johnson, Alison M. LaCarrubba, Lynn M. Martin, Aaron C. Ericsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ddc4788c01b42e4bbde004fafa925ed
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spelling	oai:doaj.org-article:5ddc4788c01b42e4bbde004fafa925ed2021-12-02T16:30:24ZExodontia associated bacteremia in horses characterized by next generation sequencing10.1038/s41598-021-85484-z2045-2322https://doaj.org/article/5ddc4788c01b42e4bbde004fafa925ed2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85484-zhttps://doaj.org/toc/2045-2322Abstract Bacteremia resulting from dental surgery is increasingly recognized as a health risk, especially in older and immunocompromised patients. Dentistry-associated bacteremia can lead to remote infections, as exemplified by valvular endocarditis. Emerging evidence points to a novel role played by oral cavity commensals in the pathogenesis of diabetes, respiratory disease, cardiovascular disease, and adverse pregnancy outcomes. Whether dental extraction, a commonly undertaken procedure in old horses, causes bacteremia has not been reported extensively. In a prospective clinical study using next generation sequencing (based on bacterial 16S rRNA), the circulating blood microbiome was characterized before and at 1 h following extraction of incisor, canine or cheek teeth from 29 adult horses with dental disease. 16S rRNA gene sequencing results from the blood microbiome were compared with those from gingival swab samples obtained prior to extraction at the location of the diseased tooth. Bacteremia associated with translocated gingival commensals was demonstrated in horses undergoing exodontia and was, in some cases, still evident one hour post-operatively.Kile S. TownsendPhilip J. JohnsonAlison M. LaCarrubbaLynn M. MartinAaron C. EricssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kile S. Townsend Philip J. Johnson Alison M. LaCarrubba Lynn M. Martin Aaron C. Ericsson Exodontia associated bacteremia in horses characterized by next generation sequencing
description	Abstract Bacteremia resulting from dental surgery is increasingly recognized as a health risk, especially in older and immunocompromised patients. Dentistry-associated bacteremia can lead to remote infections, as exemplified by valvular endocarditis. Emerging evidence points to a novel role played by oral cavity commensals in the pathogenesis of diabetes, respiratory disease, cardiovascular disease, and adverse pregnancy outcomes. Whether dental extraction, a commonly undertaken procedure in old horses, causes bacteremia has not been reported extensively. In a prospective clinical study using next generation sequencing (based on bacterial 16S rRNA), the circulating blood microbiome was characterized before and at 1 h following extraction of incisor, canine or cheek teeth from 29 adult horses with dental disease. 16S rRNA gene sequencing results from the blood microbiome were compared with those from gingival swab samples obtained prior to extraction at the location of the diseased tooth. Bacteremia associated with translocated gingival commensals was demonstrated in horses undergoing exodontia and was, in some cases, still evident one hour post-operatively.
format	article
author	Kile S. Townsend Philip J. Johnson Alison M. LaCarrubba Lynn M. Martin Aaron C. Ericsson
author_facet	Kile S. Townsend Philip J. Johnson Alison M. LaCarrubba Lynn M. Martin Aaron C. Ericsson
author_sort	Kile S. Townsend
title	Exodontia associated bacteremia in horses characterized by next generation sequencing
title_short	Exodontia associated bacteremia in horses characterized by next generation sequencing
title_full	Exodontia associated bacteremia in horses characterized by next generation sequencing
title_fullStr	Exodontia associated bacteremia in horses characterized by next generation sequencing
title_full_unstemmed	Exodontia associated bacteremia in horses characterized by next generation sequencing
title_sort	exodontia associated bacteremia in horses characterized by next generation sequencing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5ddc4788c01b42e4bbde004fafa925ed
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Exodontia associated bacteremia in horses characterized by next generation sequencing

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