Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages show different response rates, and ICI responder...

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Autores principales:	Sara De Biasi, Lara Gibellini, Domenico Lo Tartaro, Simone Puccio, Claudio Rabacchi, Emilia M. C. Mazza, Jolanda Brummelman, Brandon Williams, Kelly Kaihara, Mattia Forcato, Silvio Bicciato, Marcello Pinti, Roberta Depenni, Roberto Sabbatini, Caterina Longo, Massimo Dominici, Giovanni Pellacani, Enrico Lugli, Andrea Cossarizza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5dde8cd7955f4749b3113f29084ac913
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spelling	oai:doaj.org-article:5dde8cd7955f4749b3113f29084ac9132021-12-02T13:17:40ZCirculating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy10.1038/s41467-021-21928-42041-1723https://doaj.org/article/5dde8cd7955f4749b3113f29084ac9132021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21928-4https://doaj.org/toc/2041-1723Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages show different response rates, and ICI responders have more MAIT cells expressing CXCR4 and granzyme B.Sara De BiasiLara GibelliniDomenico Lo TartaroSimone PuccioClaudio RabacchiEmilia M. C. MazzaJolanda BrummelmanBrandon WilliamsKelly KaiharaMattia ForcatoSilvio BicciatoMarcello PintiRoberta DepenniRoberto SabbatiniCaterina LongoMassimo DominiciGiovanni PellacaniEnrico LugliAndrea CossarizzaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara De Biasi Lara Gibellini Domenico Lo Tartaro Simone Puccio Claudio Rabacchi Emilia M. C. Mazza Jolanda Brummelman Brandon Williams Kelly Kaihara Mattia Forcato Silvio Bicciato Marcello Pinti Roberta Depenni Roberto Sabbatini Caterina Longo Massimo Dominici Giovanni Pellacani Enrico Lugli Andrea Cossarizza Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
description	Immune checkpoint inhibition (ICI) shows potential for cancer therapies, but response rates vary. Here, the authors use single-cell analyses to show that, in a 28 patient cohort, patients stratified by mucosal-associated invariant T (MAIT) percentages show different response rates, and ICI responders have more MAIT cells expressing CXCR4 and granzyme B.
format	article
author	Sara De Biasi Lara Gibellini Domenico Lo Tartaro Simone Puccio Claudio Rabacchi Emilia M. C. Mazza Jolanda Brummelman Brandon Williams Kelly Kaihara Mattia Forcato Silvio Bicciato Marcello Pinti Roberta Depenni Roberto Sabbatini Caterina Longo Massimo Dominici Giovanni Pellacani Enrico Lugli Andrea Cossarizza
author_facet	Sara De Biasi Lara Gibellini Domenico Lo Tartaro Simone Puccio Claudio Rabacchi Emilia M. C. Mazza Jolanda Brummelman Brandon Williams Kelly Kaihara Mattia Forcato Silvio Bicciato Marcello Pinti Roberta Depenni Roberto Sabbatini Caterina Longo Massimo Dominici Giovanni Pellacani Enrico Lugli Andrea Cossarizza
author_sort	Sara De Biasi
title	Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
title_short	Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
title_full	Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
title_fullStr	Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
title_full_unstemmed	Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
title_sort	circulating mucosal-associated invariant t cells identify patients responding to anti-pd-1 therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5dde8cd7955f4749b3113f29084ac913
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Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

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