Dissociative states in borderline personality disorder and their relationships to psychotropic medication

Ondrej Pec,1,2 Petr Bob,1,3 Jakub Simek,1 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 2Psychotherapeutic and Psychosomatic Clinic ESET, Prague, Czech Republic; 3Centra...

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Autores principales:	Pec O, Bob P, Simek J, Raboch J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	dissociation stress antipsychotics antidepressants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5ddf5f9418d84fffa9a5b3db6a5206a7
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spelling	oai:doaj.org-article:5ddf5f9418d84fffa9a5b3db6a5206a72021-12-02T03:50:35ZDissociative states in borderline personality disorder and their relationships to psychotropic medication1178-2021https://doaj.org/article/5ddf5f9418d84fffa9a5b3db6a5206a72018-11-01T00:00:00Zhttps://www.dovepress.com/dissociative-states-in-borderline-personality-disorder-and-their-relat-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ondrej Pec,1,2 Petr Bob,1,3 Jakub Simek,1 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 2Psychotherapeutic and Psychosomatic Clinic ESET, Prague, Czech Republic; 3Central European Institute of Technology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Background: According to recent data, dissociation may play an important role in borderline personality disorder (BPD), nevertheless specific influences of psychotropic medication on dissociative symptoms in BPD and their therapeutic indications are largely unknown. The purpose of this study was to assess relationships of dissociative symptoms in BPD patients with levels of psychotropic medication and compare these results with a subgroup of patients with schizophrenia. Materials and methods: In this study, we investigated 52 BPD patients and compared the results with a control group of 36 schizophrenia patients. In all participants, we assessed actual day doses of antipsychotic medication in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents. Dissociative symptoms were measured by Dissociative Experiences Scale (DES), and other psychopathological symptoms were measured using Health of the Nation Outcome Scales. Results: Results indicate that dissociative symptoms measured by DES were significantly correlated with antipsychotic medication (Spearman R=0.45, P<0.01) in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents (0.36, P<0.01). These relationships between medication and dissociative symptoms were not found in the control group of schizophrenia patients. Conclusion: The results suggest that levels of antipsychotic medication and antidepressant medication are significantly associated with dissociative symptoms in BPD but not in schizophrenia. Keywords: dissociation, stress, antipsychotics, antidepressantsPec OBob PSimek JRaboch JDove Medical PressarticledissociationstressantipsychoticsantidepressantsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3253-3257 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	dissociation stress antipsychotics antidepressants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	dissociation stress antipsychotics antidepressants Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pec O Bob P Simek J Raboch J Dissociative states in borderline personality disorder and their relationships to psychotropic medication
description	Ondrej Pec,1,2 Petr Bob,1,3 Jakub Simek,1 Jiri Raboch1 1Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic; 2Psychotherapeutic and Psychosomatic Clinic ESET, Prague, Czech Republic; 3Central European Institute of Technology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Background: According to recent data, dissociation may play an important role in borderline personality disorder (BPD), nevertheless specific influences of psychotropic medication on dissociative symptoms in BPD and their therapeutic indications are largely unknown. The purpose of this study was to assess relationships of dissociative symptoms in BPD patients with levels of psychotropic medication and compare these results with a subgroup of patients with schizophrenia. Materials and methods: In this study, we investigated 52 BPD patients and compared the results with a control group of 36 schizophrenia patients. In all participants, we assessed actual day doses of antipsychotic medication in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents. Dissociative symptoms were measured by Dissociative Experiences Scale (DES), and other psychopathological symptoms were measured using Health of the Nation Outcome Scales. Results: Results indicate that dissociative symptoms measured by DES were significantly correlated with antipsychotic medication (Spearman R=0.45, P<0.01) in chlorpromazine equivalents and antidepressant medication in fluoxetine equivalents (0.36, P<0.01). These relationships between medication and dissociative symptoms were not found in the control group of schizophrenia patients. Conclusion: The results suggest that levels of antipsychotic medication and antidepressant medication are significantly associated with dissociative symptoms in BPD but not in schizophrenia. Keywords: dissociation, stress, antipsychotics, antidepressants
format	article
author	Pec O Bob P Simek J Raboch J
author_facet	Pec O Bob P Simek J Raboch J
author_sort	Pec O
title	Dissociative states in borderline personality disorder and their relationships to psychotropic medication
title_short	Dissociative states in borderline personality disorder and their relationships to psychotropic medication
title_full	Dissociative states in borderline personality disorder and their relationships to psychotropic medication
title_fullStr	Dissociative states in borderline personality disorder and their relationships to psychotropic medication
title_full_unstemmed	Dissociative states in borderline personality disorder and their relationships to psychotropic medication
title_sort	dissociative states in borderline personality disorder and their relationships to psychotropic medication
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5ddf5f9418d84fffa9a5b3db6a5206a7
work_keys_str_mv	AT peco dissociativestatesinborderlinepersonalitydisorderandtheirrelationshipstopsychotropicmedication AT bobp dissociativestatesinborderlinepersonalitydisorderandtheirrelationshipstopsychotropicmedication AT simekj dissociativestatesinborderlinepersonalitydisorderandtheirrelationshipstopsychotropicmedication AT rabochj dissociativestatesinborderlinepersonalitydisorderandtheirrelationshipstopsychotropicmedication
_version_	1718401602101968896

Dissociative states in borderline personality disorder and their relationships to psychotropic medication

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