Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management

ABSTRACT Immunology has been studied and understood in the context of the compelling problems of infectious disease. But our rapidly growing knowledge of immune interactions with our healthy microbiota, and the many benefits it confers, suggests there may be value to an alternative view: that mechan...

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Autor principal:	Eric T. Harvill
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5de06f969f7d402eb5d5fe24375fe685
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spelling	oai:doaj.org-article:5de06f969f7d402eb5d5fe24375fe6852021-11-15T15:40:29ZCultivating Our “Frienemies”: Viewing Immunity as Microbiome Management10.1128/mBio.00027-132150-7511https://doaj.org/article/5de06f969f7d402eb5d5fe24375fe6852013-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00027-13https://doaj.org/toc/2150-7511ABSTRACT Immunology has been studied and understood in the context of the compelling problems of infectious disease. But our rapidly growing knowledge of immune interactions with our healthy microbiota, and the many benefits it confers, suggests there may be value to an alternative view: that mechanisms of defense against pathogens are one aspect of a complex system with the broader purpose of managing our healthy microbiome. From this perspective, adaptive immunity may be viewed as a flexible system for simultaneously recruiting and managing a near limitless number of potential symbionts. This perspective can allow for reinterpretation of many observations and can suggest new experiments to help us better understand our complex interactions with the microbes that surround us.Eric T. HarvillAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 2 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Eric T. Harvill Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
description	ABSTRACT Immunology has been studied and understood in the context of the compelling problems of infectious disease. But our rapidly growing knowledge of immune interactions with our healthy microbiota, and the many benefits it confers, suggests there may be value to an alternative view: that mechanisms of defense against pathogens are one aspect of a complex system with the broader purpose of managing our healthy microbiome. From this perspective, adaptive immunity may be viewed as a flexible system for simultaneously recruiting and managing a near limitless number of potential symbionts. This perspective can allow for reinterpretation of many observations and can suggest new experiments to help us better understand our complex interactions with the microbes that surround us.
format	article
author	Eric T. Harvill
author_facet	Eric T. Harvill
author_sort	Eric T. Harvill
title	Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
title_short	Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
title_full	Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
title_fullStr	Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
title_full_unstemmed	Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management
title_sort	cultivating our “frienemies”: viewing immunity as microbiome management
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/5de06f969f7d402eb5d5fe24375fe685
work_keys_str_mv	AT erictharvill cultivatingourfrienemiesviewingimmunityasmicrobiomemanagement
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Cultivating Our “Frienemies”: Viewing Immunity as Microbiome Management

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