Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy

Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics in pigs, and model its impact on viral resistance...

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Autores principales:	Ameya R. Kirtane, Omar Abouzid, Daniel Minahan, Taylor Bensel, Alison L. Hill, Christian Selinger, Anna Bershteyn, Morgan Craig, Shirley S. Mo, Hormoz Mazdiyasni, Cody Cleveland, Jaimie Rogner, Young-Ah Lucy Lee, Lucas Booth, Farhad Javid, Sarah J. Wu, Tyler Grant, Andrew M. Bellinger, Boris Nikolic, Alison Hayward, Lowell Wood, Philip A. Eckhoff, Martin A. Nowak, Robert Langer, Giovanni Traverso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5de2bff495f541e8ae208242e10f066e
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spelling	oai:doaj.org-article:5de2bff495f541e8ae208242e10f066e2021-12-02T17:31:31ZDevelopment of an oral once-weekly drug delivery system for HIV antiretroviral therapy10.1038/s41467-017-02294-62041-1723https://doaj.org/article/5de2bff495f541e8ae208242e10f066e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02294-6https://doaj.org/toc/2041-1723Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics in pigs, and model its impact on viral resistance and disease epidemics.Ameya R. KirtaneOmar AbouzidDaniel MinahanTaylor BenselAlison L. HillChristian SelingerAnna BershteynMorgan CraigShirley S. MoHormoz MazdiyasniCody ClevelandJaimie RognerYoung-Ah Lucy LeeLucas BoothFarhad JavidSarah J. WuTyler GrantAndrew M. BellingerBoris NikolicAlison HaywardLowell WoodPhilip A. EckhoffMartin A. NowakRobert LangerGiovanni TraversoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ameya R. Kirtane Omar Abouzid Daniel Minahan Taylor Bensel Alison L. Hill Christian Selinger Anna Bershteyn Morgan Craig Shirley S. Mo Hormoz Mazdiyasni Cody Cleveland Jaimie Rogner Young-Ah Lucy Lee Lucas Booth Farhad Javid Sarah J. Wu Tyler Grant Andrew M. Bellinger Boris Nikolic Alison Hayward Lowell Wood Philip A. Eckhoff Martin A. Nowak Robert Langer Giovanni Traverso Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
description	Poor adherence to daily antiretrovirals can significantly affect treatment efficacy, but oral long-acting antiretrovirals are currently lacking. Here, the authors develop a once-weekly oral dosage form for anti-HIV drugs, assess its pharmacokinetics in pigs, and model its impact on viral resistance and disease epidemics.
format	article
author	Ameya R. Kirtane Omar Abouzid Daniel Minahan Taylor Bensel Alison L. Hill Christian Selinger Anna Bershteyn Morgan Craig Shirley S. Mo Hormoz Mazdiyasni Cody Cleveland Jaimie Rogner Young-Ah Lucy Lee Lucas Booth Farhad Javid Sarah J. Wu Tyler Grant Andrew M. Bellinger Boris Nikolic Alison Hayward Lowell Wood Philip A. Eckhoff Martin A. Nowak Robert Langer Giovanni Traverso
author_facet	Ameya R. Kirtane Omar Abouzid Daniel Minahan Taylor Bensel Alison L. Hill Christian Selinger Anna Bershteyn Morgan Craig Shirley S. Mo Hormoz Mazdiyasni Cody Cleveland Jaimie Rogner Young-Ah Lucy Lee Lucas Booth Farhad Javid Sarah J. Wu Tyler Grant Andrew M. Bellinger Boris Nikolic Alison Hayward Lowell Wood Philip A. Eckhoff Martin A. Nowak Robert Langer Giovanni Traverso
author_sort	Ameya R. Kirtane
title	Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
title_short	Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
title_full	Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
title_fullStr	Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
title_full_unstemmed	Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
title_sort	development of an oral once-weekly drug delivery system for hiv antiretroviral therapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5de2bff495f541e8ae208242e10f066e
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Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy

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