Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.

Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice...

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Autores principales:	Susanne Meis, Jorge Ricardo Bergado-Acosta, Yuchio Yanagawa, Kunihiko Obata, Oliver Stork, Thomas Munsch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5de2d7cdd9004069a827caa5ab3795f7
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spelling	oai:doaj.org-article:5de2d7cdd9004069a827caa5ab3795f72021-11-25T06:11:34ZIdentification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.1932-620310.1371/journal.pone.0002695https://doaj.org/article/5de2d7cdd9004069a827caa5ab3795f72008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18628994/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice preparations, we demonstrate that NPS directly activates an inward current in 20% of EPN neurons and evokes an increase of glutamatergic excitation in this nucleus. Excitation of the EPN is responsible for a modulation of BLA activity through NPS, characterized by a general increase of GABAergic inhibition and enhancement of spike activity in a subset of BLA projection neurons. Finally, local injection of NPS to the EPN interferes with the expression of contextual, but not auditory cued fear memory. Together, these data suggest the existence of a specific NPS-responsive circuitry between EPN and BLA, likely involved in contextual aspects of fear memory.Susanne MeisJorge Ricardo Bergado-AcostaYuchio YanagawaKunihiko ObataOliver StorkThomas MunschPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2695 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanne Meis Jorge Ricardo Bergado-Acosta Yuchio Yanagawa Kunihiko Obata Oliver Stork Thomas Munsch Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
description	Neuropeptide S (NPS) and its receptor are thought to define a set of specific brain circuits involved in fear and anxiety. Here we provide evidence for a novel, NPS-responsive circuit that shapes neural activity in the mouse basolateral amygdala (BLA) via the endopiriform nucleus (EPN). Using slice preparations, we demonstrate that NPS directly activates an inward current in 20% of EPN neurons and evokes an increase of glutamatergic excitation in this nucleus. Excitation of the EPN is responsible for a modulation of BLA activity through NPS, characterized by a general increase of GABAergic inhibition and enhancement of spike activity in a subset of BLA projection neurons. Finally, local injection of NPS to the EPN interferes with the expression of contextual, but not auditory cued fear memory. Together, these data suggest the existence of a specific NPS-responsive circuitry between EPN and BLA, likely involved in contextual aspects of fear memory.
format	article
author	Susanne Meis Jorge Ricardo Bergado-Acosta Yuchio Yanagawa Kunihiko Obata Oliver Stork Thomas Munsch
author_facet	Susanne Meis Jorge Ricardo Bergado-Acosta Yuchio Yanagawa Kunihiko Obata Oliver Stork Thomas Munsch
author_sort	Susanne Meis
title	Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
title_short	Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
title_full	Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
title_fullStr	Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
title_full_unstemmed	Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.
title_sort	identification of a neuropeptide s responsive circuitry shaping amygdala activity via the endopiriform nucleus.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/5de2d7cdd9004069a827caa5ab3795f7
work_keys_str_mv	AT susannemeis identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus AT jorgericardobergadoacosta identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus AT yuchioyanagawa identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus AT kunihikoobata identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus AT oliverstork identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus AT thomasmunsch identificationofaneuropeptidesresponsivecircuitryshapingamygdalaactivityviatheendopiriformnucleus
_version_	1718414043504443392

Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus.

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