Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution

The conformational heterogeneity of RNA molecules makes their structure determination by X-ray crystallography and NMR challenging. Here the authors show that RNA structures can be solved by cryo-EM and present the structures of a 40 kDa SAM-IV riboswitch in the apo form and bound to its ligand S-ad...

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Bibliographic Details
Main Authors: Kaiming Zhang, Shanshan Li, Kalli Kappel, Grigore Pintilie, Zhaoming Su, Tung-Chung Mou, Michael F. Schmid, Rhiju Das, Wah Chiu
Format: article
Language:EN
Published: Nature Portfolio 2019
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Online Access:https://doaj.org/article/5de6b22e3c6a4ad29f1e5dabe8c50f5e
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