COVID vaccination and asthma exacerbation: might there be a link?

ABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 201...

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Autores principales:	Marta Colaneri, Maria De Filippo, Amelia Licari, Alessia Marseglia, Laura Maiocchi, Alessandra Ricciardi, Angelo Corsico, Gianluigi Marseglia, Mario Umberto Mondelli, Raffaele Bruno
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	SARS-CoV-2 Asthma exacerbation Monoclonal antibody against interleukin-5 COVID-19 vaccination Long COVID Mass vaccination Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/5de753d6a4714c3ea67ec1024a75a10d
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spelling	oai:doaj.org-article:5de753d6a4714c3ea67ec1024a75a10d2021-11-30T04:14:15ZCOVID vaccination and asthma exacerbation: might there be a link?1201-971210.1016/j.ijid.2021.09.026https://doaj.org/article/5de753d6a4714c3ea67ec1024a75a10d2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007335https://doaj.org/toc/1201-9712ABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 2019 (COVID-19) vaccination on asthma is entirely unexplored. Case study: This study examined a challenging case of severe asthma exacerbation in a 28-year-old female following two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at IRCCS Policlinico San Matteo in Pavia, Italy. The patient, a fourth-year resident at the hospital, was vaccinated in early 2021. She was an occasional smoker with a 10-year history of asthma and seasonal allergic rhinitis. She tested negative for SARS-CoV-2 on several molecular swabs and serology tests. Results: After receiving the second dose of vaccine, the patient started to experience worsening of respiratory symptoms. Following several episodes and a severe asthma attack, the patient required treatment with mepolizumab, a biologic drug (interleukin-5) antagonist monoclonal antibody. Conclusion: This single case study is insufficient to draw conclusions about the association between asthma exacerbation and the COVID-19 vaccine. While the cause–effect link between vaccination against SARS-CoV-2 and worsening of asthmatic disease might only be suggested at present, this case is a valuable prompt for further investigation. This is particularly true from the perspective of mass vaccination of adolescents and children currently underway across the globe.Marta ColaneriMaria De FilippoAmelia LicariAlessia MarsegliaLaura MaiocchiAlessandra RicciardiAngelo CorsicoGianluigi MarsegliaMario Umberto MondelliRaffaele BrunoElsevierarticleSARS-CoV-2Asthma exacerbationMonoclonal antibody against interleukin-5COVID-19 vaccinationLong COVIDMass vaccinationInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 243-246 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Asthma exacerbation Monoclonal antibody against interleukin-5 COVID-19 vaccination Long COVID Mass vaccination Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 Asthma exacerbation Monoclonal antibody against interleukin-5 COVID-19 vaccination Long COVID Mass vaccination Infectious and parasitic diseases RC109-216 Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno COVID vaccination and asthma exacerbation: might there be a link?
description	ABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 2019 (COVID-19) vaccination on asthma is entirely unexplored. Case study: This study examined a challenging case of severe asthma exacerbation in a 28-year-old female following two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at IRCCS Policlinico San Matteo in Pavia, Italy. The patient, a fourth-year resident at the hospital, was vaccinated in early 2021. She was an occasional smoker with a 10-year history of asthma and seasonal allergic rhinitis. She tested negative for SARS-CoV-2 on several molecular swabs and serology tests. Results: After receiving the second dose of vaccine, the patient started to experience worsening of respiratory symptoms. Following several episodes and a severe asthma attack, the patient required treatment with mepolizumab, a biologic drug (interleukin-5) antagonist monoclonal antibody. Conclusion: This single case study is insufficient to draw conclusions about the association between asthma exacerbation and the COVID-19 vaccine. While the cause–effect link between vaccination against SARS-CoV-2 and worsening of asthmatic disease might only be suggested at present, this case is a valuable prompt for further investigation. This is particularly true from the perspective of mass vaccination of adolescents and children currently underway across the globe.
format	article
author	Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno
author_facet	Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno
author_sort	Marta Colaneri
title	COVID vaccination and asthma exacerbation: might there be a link?
title_short	COVID vaccination and asthma exacerbation: might there be a link?
title_full	COVID vaccination and asthma exacerbation: might there be a link?
title_fullStr	COVID vaccination and asthma exacerbation: might there be a link?
title_full_unstemmed	COVID vaccination and asthma exacerbation: might there be a link?
title_sort	covid vaccination and asthma exacerbation: might there be a link?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5de753d6a4714c3ea67ec1024a75a10d
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COVID vaccination and asthma exacerbation: might there be a link?

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