Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

Many cohort studies have investigated the link between diet and plasma TMAO levels, reporting incongruent results, while gut microbiota were only recently included into analyses. In these studies, taxonomic data were recorded that are not a good proxy for TMA formation, as specific members of vario...

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Autores principales:	Silke Rath, Katharina Rox, Sven Kleine Bardenhorst, Ulf Schminke, Marcus Dörr, Julia Mayerle, Fabian Frost, Markus M. Lerch, André Karch, Mark Brönstrup, Dietmar H. Pieper, Marius Vital
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/5de86fa11c914a228de9fbfcdf2921f5
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spelling	oai:doaj.org-article:5de86fa11c914a228de9fbfcdf2921f52021-12-02T16:51:26Z Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria 2379-507710.1128/mSystems.00945-21https://doaj.org/article/5de86fa11c914a228de9fbfcdf2921f52021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00945-21https://doaj.org/toc/2379-5077 Many cohort studies have investigated the link between diet and plasma TMAO levels, reporting incongruent results, while gut microbiota were only recently included into analyses. In these studies, taxonomic data were recorded that are not a good proxy for TMA formation, as specific members of various taxa exhibit genes catalyzing this reaction, demanding function-based technologies for accurate quantification of TMA-synthesizing bacteria.Silke RathKatharina RoxSven Kleine BardenhorstUlf SchminkeMarcus DörrJulia MayerleFabian FrostMarkus M. LerchAndré KarchMark BrönstrupDietmar H. PieperMarius VitalAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Silke Rath Katharina Rox Sven Kleine Bardenhorst Ulf Schminke Marcus Dörr Julia Mayerle Fabian Frost Markus M. Lerch André Karch Mark Brönstrup Dietmar H. Pieper Marius Vital Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
description	Many cohort studies have investigated the link between diet and plasma TMAO levels, reporting incongruent results, while gut microbiota were only recently included into analyses. In these studies, taxonomic data were recorded that are not a good proxy for TMA formation, as specific members of various taxa exhibit genes catalyzing this reaction, demanding function-based technologies for accurate quantification of TMA-synthesizing bacteria.
format	article
author	Silke Rath Katharina Rox Sven Kleine Bardenhorst Ulf Schminke Marcus Dörr Julia Mayerle Fabian Frost Markus M. Lerch André Karch Mark Brönstrup Dietmar H. Pieper Marius Vital
author_facet	Silke Rath Katharina Rox Sven Kleine Bardenhorst Ulf Schminke Marcus Dörr Julia Mayerle Fabian Frost Markus M. Lerch André Karch Mark Brönstrup Dietmar H. Pieper Marius Vital
author_sort	Silke Rath
title	Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
title_short	Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
title_full	Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
title_fullStr	Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
title_full_unstemmed	Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria
title_sort	higher trimethylamine- <i>n</i> -oxide plasma levels with increasing age are mediated by diet and trimethylamine-forming bacteria
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/5de86fa11c914a228de9fbfcdf2921f5
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Higher Trimethylamine- <i>N</i> -Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

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