Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mic...

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Autores principales:	Doo Ri Park, Jihee Kim, Gyeong Min Kim, Haeseung Lee, Minhee Kim, Donghyun Hwang, Hana Lee, Han-Sung Kim, Wankyu Kim, Min Chan Park, Hyunbo Shim, Soo Young Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5de8b89375a3490286669ccd5365ba62
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spelling	oai:doaj.org-article:5de8b89375a3490286669ccd5365ba622021-12-02T16:34:55ZOsteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation10.1038/s41467-020-18208-y2041-1723https://doaj.org/article/5de8b89375a3490286669ccd5365ba622020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18208-yhttps://doaj.org/toc/2041-1723Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mice by decreasing chondrocyte apoptosis.Doo Ri ParkJihee KimGyeong Min KimHaeseung LeeMinhee KimDonghyun HwangHana LeeHan-Sung KimWankyu KimMin Chan ParkHyunbo ShimSoo Young LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Doo Ri Park Jihee Kim Gyeong Min Kim Haeseung Lee Minhee Kim Donghyun Hwang Hana Lee Han-Sung Kim Wankyu Kim Min Chan Park Hyunbo Shim Soo Young Lee Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
description	Osteoarthritis (OA) is associated with cartilage disruption, but the underlying mechanisms remain unclear. Here, the authors show that expression of osteoclast-associated receptor (OSCAR) is associated with OA, that its genetic ablation or targeting with OSCAR-Fc fusion protein ameliorates OA in mice by decreasing chondrocyte apoptosis.
format	article
author	Doo Ri Park Jihee Kim Gyeong Min Kim Haeseung Lee Minhee Kim Donghyun Hwang Hana Lee Han-Sung Kim Wankyu Kim Min Chan Park Hyunbo Shim Soo Young Lee
author_facet	Doo Ri Park Jihee Kim Gyeong Min Kim Haeseung Lee Minhee Kim Donghyun Hwang Hana Lee Han-Sung Kim Wankyu Kim Min Chan Park Hyunbo Shim Soo Young Lee
author_sort	Doo Ri Park
title	Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
title_short	Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
title_full	Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
title_fullStr	Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
title_full_unstemmed	Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
title_sort	osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5de8b89375a3490286669ccd5365ba62
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Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation

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