Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate

Titers of monoterpenoids production in yeast are low due to the fact that the geranyl diphosphate (GPP)-based pathway can redirect metabolic fluxes to growth. Here, the authors build an orthogonal pathway by selecting the cis isomer of GPP as an alternative precursor and achieve high titer monoterpe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Codruta Ignea, Morten H. Raadam, Mohammed S. Motawia, Antonios M. Makris, Claudia E. Vickers, Sotirios C. Kampranis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5de8de4ce8a04318b1738fc8284a2b44
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5de8de4ce8a04318b1738fc8284a2b44
record_format	dspace
spelling	oai:doaj.org-article:5de8de4ce8a04318b1738fc8284a2b442021-12-02T14:40:18ZOrthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate10.1038/s41467-019-11290-x2041-1723https://doaj.org/article/5de8de4ce8a04318b1738fc8284a2b442019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11290-xhttps://doaj.org/toc/2041-1723Titers of monoterpenoids production in yeast are low due to the fact that the geranyl diphosphate (GPP)-based pathway can redirect metabolic fluxes to growth. Here, the authors build an orthogonal pathway by selecting the cis isomer of GPP as an alternative precursor and achieve high titer monoterpene production.Codruta IgneaMorten H. RaadamMohammed S. MotawiaAntonios M. MakrisClaudia E. VickersSotirios C. KampranisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Codruta Ignea Morten H. Raadam Mohammed S. Motawia Antonios M. Makris Claudia E. Vickers Sotirios C. Kampranis Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
description	Titers of monoterpenoids production in yeast are low due to the fact that the geranyl diphosphate (GPP)-based pathway can redirect metabolic fluxes to growth. Here, the authors build an orthogonal pathway by selecting the cis isomer of GPP as an alternative precursor and achieve high titer monoterpene production.
format	article
author	Codruta Ignea Morten H. Raadam Mohammed S. Motawia Antonios M. Makris Claudia E. Vickers Sotirios C. Kampranis
author_facet	Codruta Ignea Morten H. Raadam Mohammed S. Motawia Antonios M. Makris Claudia E. Vickers Sotirios C. Kampranis
author_sort	Codruta Ignea
title	Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
title_short	Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
title_full	Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
title_fullStr	Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
title_full_unstemmed	Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
title_sort	orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5de8de4ce8a04318b1738fc8284a2b44
work_keys_str_mv	AT codrutaignea orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate AT mortenhraadam orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate AT mohammedsmotawia orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate AT antoniosmmakris orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate AT claudiaevickers orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate AT sotiriosckampranis orthogonalmonoterpenoidbiosynthesisinyeastconstructedonanisomericsubstrate
_version_	1718390357014609920

Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate

Ejemplares similares